908 Devices and Cellares Collaborate to Integrate In-line Monitoring of Bioprocess Parameters into the Cell Shuttle, Cellares’ Fully Integrated Cell Therapy Manufacturing Platform

908 Devices Inc. (Nasdaq: MASS), a pioneer of purpose-built handheld and desktop devices for chemical and biochemical analysis, and Cellares, the first Integrated Development and Manufacturing Organization (IDMO) dedicated to clinical and commercial-scale cell therapy manufacturing, announce a development collaboration to integrate in-line monitoring of key cell culture parameters into Cellares’ Cell Shuttle system, a fully integrated, scalable, cell therapy manufacturing platform. The collaboration between the two companies aims to further advance the efficiency, safety, and cost-effectiveness of large-scale cell therapy manufacturing.

908 Devices is integrating its optical in-line analyzer, MAVERICK, the first turn-key device to utilize Raman spectroscopy for bioprocess control, with no modeling or development required. MAVERICK’s purpose-built de novo models automatically process Raman spectra from a wide variety of culture media types and cell lines, delivering actionable process parameters or direct process control actions. The company is adapting its MAVERICK device to be integrated into the Cell Shuttle system.

“In-line analysis provides real-time monitoring of the cell culture process, allowing for immediate corrective action. It also maintains sample integrity, reduces contamination risk, and improves product quality,” said Christopher D. Brown, PhD, Chief Product Officer and Co-founder, 908 Devices. “We’re very proud to partner with Cellares to accelerate access to life-saving cell therapies.”

Cellares’ Cell Shuttle supports both autologous and allogeneic cell therapy processes and most cell therapy modalities. The Cell Shuttle platform integrates all the technologies required for all unit operations and is successfully running CAR-T cell therapy processes with true walk-away, end-to-end automation. Cellares’ Cell Shuttle reduces labor and facility size required by 90% compared with manual cell therapy manufacturing processes based on benchtop equipment. Consequently, Cellares’ IDMO Smart Factories can produce 10 times more cell therapy batches per year than conventional CDMO facilities, with the same footprint and the same workforce.