Angle PLC Announces Parsortix at European Breast Cancer Conference

PARSORTIX SYSTEM AND ASSAYS BEING SHOWCASED AT A LEADING EUROPEAN BREAST CANCER CONFERENCE

ANGLE presenting two posters highlighting the utility of the Company's new Portrait+ CTC Staining Kit and Portrait HER2 assay

GUILDFORD, SURREY / ACCESSWIRE / March 22, 2024 / ANGLE plc (AIM:AG)(OTCQX:ANPCY), a world-leading liquid biopsy company with innovative circulating tumour cell (CTC) solutions for use in research, drug development and clinical oncology, is pleased to announce its participation at the 14^th European Breast Cancer Conference (EBCC) being held in Milan, Italy on 20 to 22 March 2024.

EBCC is focused on multidisciplinary, high-quality clinical and translational research, with an emphasis on innovation and technology in the management of breast cancer. The conference is attended by researchers, physicians, patient advocates and industry representatives providing sales, partnership and collaboration opportunities.

ANGLE is presenting two posters at the conference:

1. Integrating isolation using label-independent microfluidics and advanced staining for comprehensive Circulating Tumour Cell Analysis

ANGLE's Parsortix system and Portrait+ CTC Staining Kit together provide an optimised, efficient, and standardised solution for the harvest and characterisation, via immunofluorescence (IF) staining, of a diverse range of CTC phenotypes. In the presented data, half of the CTC-positive breast cancer patient blood samples contained only mesenchymal CTCs, while half had a combination of both epithelial and mesenchymal CTCs. Patients with purely mesenchymal CTCs would have been missed by epitope-dependent systems. This is important because mesenchymal CTCs or CTCs undergoing epithelial-to-mesenchymal transition are clinically significant, playing a critical role in cancer progression, treatment resistance and metastasis.

CTC clusters harvested by the Parsortix system were observed in 75% of the CTC-positive patients which is crucial given that CTC clusters have been shown to have up to 100 times the increased metastatic potential compared to single CTCs. The Parsortix cassette's unique design is suited to capturing and harvesting clusters which is often difficult with other CTC systems.

The study results highlight the importance of using ANGLE's Parsortix system combined with the Company's Portrait+ CTC Staining Kit, to enable the isolation and analysis of a range of CTC phenotypes and CTC clusters, both of which are important in cancer progression and metastasis.