Top Line Results From Aironite Phase 2 Clinical Trial for the Treatment of HFpEF to Be Presented at American College of Cardiology 67th Annual Scientific Sessions & Expo on March 11th - Seite 2

About Aironite
Aironite is a sodium nitrite solution for inhalation via nebulization in Phase 2 clinical trials in patients with HFpEF. Nitrite is a direct vasodilator and can be recycled in vivo to form nitric oxide (NO) independent of the classical NO synthase (NOS) pathway. Nitrite and Nitrite-mediated NO formation have multiple beneficial effects, including dilation of blood vessels, reduction in hemodynamic perturbations during exercise in the failing heart, and improvements in skeletal muscle bioenergetics and mitochondrial respiration, resulting in improved efficiency of oxygen utilization during submaximal exercise.

In addition to the INDIE-HFpEF study, Savara is also supporting a complementary, double blind, placebo-controlled institution-sponsored Phase 2 study of Aironite in patients with HFpEF, referred to as the INABLE study. The main objective of the INABLE study is to assess the efficacy of Aironite on the same outcome measures as in the INDIE-HFpEF study, but when used in conjunction with supervised cardiac rehabilitation exercise training. Supervised exercise training for HFpEF patients is the only therapeutic intervention to have demonstrated improvements in exercise capacity and quality of life in patients managed with nonspecific heart failure medications, thus the INABLE study is designed to demonstrate Aironite's ability to amplify this benefit.

About the Heart Failure Clinical Research Network (HFN)
The HFN was established by the National Heart, Lung, and Blood Institute (NHLBI) to expedite clinical research on treatments and strategies to improve the management of acute and chronic heart failure. The HFN's work is supported by a grant awarded by the NHLBI, part of the National Institutes of Health (NIH). The HFN provides a unique platform for collaborative research by bringing together many premier centers across North America. The HFN is composed of nine Regional Coordinating Centers and their affiliated sites, whose investigators provide scientific leadership in the collaborative development of the HFN's scientific agenda. The HFN is recognized for robust enrollment in heart failure clinical trials and high scientific productivity. More information can be found on the HFN's website, https://www.hfnetwork.org/.