Predictive Oncology’s TumorGenesis Division Secures First Commercial Sale of its Novel Ovarian Cancer Cell Media - Seite 3

Soluble Biotech Inc., a division of Predictive Oncology Inc. has a technology that allows the company to screen proteins for both solubility and stability. The proteins that have been successfully improved by Soluble include vaccines, antibodies and other proteins used in disease treatment. The company can screen 12,000 possible combinations of formulations of any protein using an exceedingly small amount, 25 milligrams and uses a neural network (AI) and other programs to predict the best formulation combination. It confirms the formulations by making a soluble and stable protein solution. The team at Soluble has worked on other viruses and deadly bacteria to come up with formulations of target proteins that can be used to treat, diagnose, or identify specific protein targets for later drug design. Soluble is expanding its reach by offering its services to COVID-19 antibody and vaccine developers. By having a soluble and stable antibody or vaccine candidate at the highest concentration is not only important for final delivery but is also a critical component in pre-clinical testing in animal models as well as in in vitro assays. Over the last 7 years, Soluble has worked for many large pharmaceutical and biotech companies but has also helped smaller companies that mostly outsource their development to outside service companies. Along with the 4 operating machines, each capable of 12,000 screens per machine,  it also sells individual kits for researchers whose budgets are constrained.

Soluble Biotech Inc. also specializes in removing, identifying, and isolating endotoxins from products that are used by researchers to culture cells and to help identify endotoxins that maybe hidden within a protective matrix. A notable example is its recent success in completion of a Phase 2 SBIR grant (July 2020 for final report) for the identification of endotoxins in patient samples that have HIV and are experiencing a syndrome known as ‘leaky gut’, where patients in its end result would succumb to septicemia. BioDtech’s detection of the endotoxin in the patient sample, alerts the clinician to start the appropriate therapy ahead of the presentation of the septicemia event. This test also works for patients with Crohn’s disease, ulcerative colitis disease or as a side effect of other drug treatments, such as chemotherapy and radiation. BioDtech’s products include a column of beads that extract endotoxins from samples as well as other kits to release bound endotoxins, improving their detection.