Trevena, Inc. Announces Presentations at the Virtual 2020 American College of Clinical Pharmacology Annual Meeting

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Live presentation highlighting TRV027 as a potential treatment for COVID-19 acute respiratory distress syndrome (ARDS) / abnormal clotting

Posters on OLINVYK benefit-risk profile and TRV250 Phase 1 pharmacokinetics

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CHESTERBROOK, Pa., Sept. 21, 2020 (GLOBE NEWSWIRE) -- Trevena, Inc. (Nasdaq: TRVN), a biopharmaceutical company focused on the development and commercialization of novel medicines for patients with central nervous system (CNS) disorders, today announced three presentations at the virtual 2020 American College of Clinical Pharmacology (ACCP) Annual Meeting, taking place from September 21^st to 23^rd, 2020.

The Company will give a live presentation on TRV027, its AT₁ receptor selective agonist being studied as a potential treatment for ARDS / abnormal clotting in COVID-19. Additionally, the Company will present two posters highlighting previously published data for OLINVYK, which is approved in the U.S. for the management of acute pain, and TRV250, its delta receptor selective agonist being developed for the acute treatment of migraine.

“I am pleased at this opportunity to present compelling data from three of our programs. The interest from ACCP highlights the diversity of our novel pipeline, with multiple exciting catalysts over the next few months,” said Mark A. Demitrack, M.D., Senior Vice President and Chief Medical Officer of Trevena, Inc.

Poster Presentation Details

Live presentation: “The Use of Simulation in the Re-purposing of Drugs for COVID-19: The Example of TRV027” (8:00-9:30 a.m. ET, September 21^st, 2020)

• In a COVID-19 infection, the SARS-coronavirus-2 binds to and removes the ACE2 protein in the lungs and other organs, resulting in a hormonal imbalance of angiotensin 2 within the RAAS pathway, converging at the AT₁ receptor.
• There is significant interest in the potential utility of TRV027 in COVID-19 patients, given its unique mechanism of action at the AT₁ receptor, which is known to mediate the effects of angiotensin 2 on lung damage and abnormal coagulation.
• Simulations were conducted to determine potential therapeutic doses, which informed a proof-of-concept trial recently initiated by Imperial College London. The study will enroll 60 hospitalized, non-ventilated patients aged 18 or older with a confirmed COVID-19 infection. The primary objective of the study is to evaluate whether TRV027 reduces abnormal clotting associated with COVID-19.