Bruker Launches timsTOF HT with Greater Dynamic Range for Further Enhancing Unbiased, High-Confidence 4D Proteomics - Seite 2

At ASMS, Bruker also announced that its timsTOF SCP system with extreme sensitivity is now also available via a co-distribution agreement with Scienion, together with the CellenONE F1.4 single-cell pico-dispenser and the new ProteoChip, as a single vendor solution for unbiased, label-free single cell proteomics (SCP).

Dr. Holger Eickhoff, CEO and founder of Scienion GmbH, a BICO company, commented: “We are pleased to offer this complete SCP solution together with Bruker. Through our expanded partnership we can even better address the needs of the single cell proteomics community by combining the expertise of our SCP teams for accelerated research solutions development in single cell proteomics.”

PaSER^TM with LFQ and Intelligent Acquisition Mode

At ASMS, Bruker demonstrated PaSER’s real-time data streams and feedback loops for intelligent acquisition processes: developed in collaboration with the Yates Lab at Scripps, users can impute acquisition parameters ‘on-the-fly’ based on PaSER’s real-time decision making for PTM targeting, retention time alignment, and dynamic inclusion and exclusion. This creates a smarter instrument for scheduling unseen candidates and deeper analysis.

Professor Alain van Gool, Head of the Translational Metabolic Laboratory at the Radboud university medical center in Nijmegen, NL, said: “We use mass spectrometry for discovery of translational biomarkers in personalized diagnostics in inherited metabolic disorders, where we focus on expression and glycosylation of protein biomarkers, and have implemented diagnostic assays. We innovate these workflows using two timsTOFs that have proven to be fast and reliable, supported by PaSER for real-time processing, (glyco)peptide identification and adjustment of instrument parameters on-the-fly. We are excited to collaborate with Bruker within our joint Center for Translational Omics on the development of feedback-based intelligent acquisition modes for glycoproteomics in clinical applications.”

PaSER version 2023 now includes real-time label-free quantitation (LFQ) for dda-PASEF, where ‘run and done’ quantitative results are available shortly after large sample cohorts have been acquired. PaSER 2023 also incorporates TIMS DIA-NN 1.1 for dia-PASEF.

Transforming high-throughput and high-confidence discovery 4D Metabolomics

The high sensitivity timsTOF Pro 2 system assists pioneering small molecule biomarker discovery partners in revolutionizing metabolomics at unprecedented scale. New workflows for the discovery of biomarkers to accelerate drug discovery and novel natural products exploit the robustness, speed and confidence of the timsTOF platform in 4D metabolomics.