Bruker Launches timsTOF HT with Greater Dynamic Range for Further Enhancing Unbiased, High-Confidence 4D Proteomics - Seite 3

Sapient Bioanalytics LLC accelerates drug discovery by uncovering pathways associated with disease mechanism, progression and patient response by using population-level data to identify sensitive biomarkers in ultra-high throughput.

Mo Jain, MD/PhD, Founder and CEO of Sapient, explained: “Sapient’s proprietary rapid LC-MS systems allow to measure thousands of molecules, including uncharacterized compounds in samples such as blood. Our six next-gen timsTOF Pro 2 systems allow us to measure more than 11,000 small molecule biomarkers per bio-sample in 43 seconds. These systems provide unmatched capacity to measure over 10,000 bio-samples per day.”

Dr. Viswa Colluru, CEO and Founder of Enveda Biosciences, uses timsTOF Pro 2 systems to discover new compounds in nature’s chemistry at an extraordinary pace. He said: “The trapped ion-mobility collision cross-section (CCS) data provided by Bruker’s timsTOF provides unprecedented 4D resolution of the many isomers in the natural world, enabling us to find novel therapeutic compounds in complex mixtures. The timsTOF Pro 2 combines cutting-edge virtually lossless ion-mobility technology with fast high-resolution TOF detection. This combination helps us profile the natural world at scale and industrialize applications in drug discovery. Bruker’s commitment to innovation and customers makes them a great partner. We are excited to continue to redefine the boundaries of metabolomics with them.”

OligoQuest^TM enhanced RNA and Oligonucleotide characterization software

Bruker’s OligoQuest software offers enhanced RNA and oligonucleotide characterization for antisense research, RNA therapeutics, confirmation of guide RNA sequences for CRISPR, and other gene editing techniques. By exploiting the high isotopic fidelity and mass accuracy of Bruker’s maXis II and timsTOF platforms, OligoQuest enables identity confirmation by intact mass and MS2 analysis. Customers are using OligoQuest for confirmation of modified RNA sequences and base exchanges in isomeric oligonucleotides. OligoQuest fills the gap in RNA and oligonucleotide data analysis with tested algorithms, and also allowing customers to use their own oligonucleotide “alphabet” for standard or customized modifications.