Ryvu Therapeutics Presents Updated Clinical and Preclinical Data on RVU120 at the 2023 European Hematology Association Congress

• Ongoing Phase 1b Dose-Escalation Study of Single-Agent Treatment with RVU120 in Patients with AML or High-Risk MDS Shows Clinical Benefit and Favorable Safety;
• Dose-Escalation Continues, Currently Enrolling at 175 mg;
• In vivo Data Show Synergistic Effects of RVU120 in Combination with Ruxolitinib in Myeloproliferative Neoplasms;
  

KRAKOW, Poland, June 09, 2023 (GLOBE NEWSWIRE) -- Ryvu Therapeutics (WSE: RVU), a clinical-stage drug discovery and development company focusing on novel small molecule therapies that address emerging targets in oncology, today announced updated safety and efficacy data from the Phase 1b dose-escalation study of RVU120 in patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (HR-MDS) and preclinical data of RVU120 in combination with the JAK1/2 inhibitor ruxolitinib (RUX) in myeloproliferative neoplasms at the Annual European Hematology Association (EHA) 2023 Hybrid Congress, taking place June 8 – 11 in Frankfurt, Germany.

“This latest data cut from 24 evaluable patients enrolled in our ongoing Phase 1b dose-escalation trial of RVU120 monotherapy in heavily pre-treated AML and HR-MDS patients shows a manageable safety profile and promising evidence of anti-leukemic activity, with 11 out of 24 evaluable patients demonstrating a clinical benefit,” said Hendrik Nogai, M.D., Chief Medical Officer of Ryvu Therapeutics. “At higher doses of RVU120, consistently high levels of target inhibition can be achieved. We anticipate the clinical benefit will even further increase as dose-escalation progresses in patients with AML and HR-MDS. Importantly, we observed that treatment with RVU120 induces erythropoiesis, which supports further testing in patients with anemia. We are also encouraged to see that the monotherapy continues to be generally well-tolerated across all dose levels. These results support our belief that RVU120 has the potential to become a valuable treatment option for patients with AML and HR-MDS.”

Dr. Nogai continued, “We have also explored the potential synergistic effects between RVU120 and RUX in myeloproliferative neoplasms. Our data suggest that the combination of RVU120 and RUX leads to a substantial reduction in the manifestation of the disease in vitro and in vivo. We are impressed by the reduction of fibrosis in the bone marrow, which is not observed with currently available treatment options. These findings reinforce the potential of co-targeting CDK8/19 and JAK1/2 as a promising approach in the treatment of myeloproliferative neoplasms.”