Innate Pharma to Present Nectin-4 Antibody Drug Conjugate IPH45 Preclinical Data at AACR 2024

Regulatory News:

Innate Pharma SA (Euronext Paris: IPH; Nasdaq: IPHA) (“Innate” or the “Company”) today announced that an abstract regarding its preclinical asset IPH45, a novel and differentiated topoisomerase I inhibitor Antibody Drug Conjugate (ADC) targeting Nectin-4, has been selected for oral presentation at the American Association for Cancer Research (AACR) Annual Meeting 2024, taking place April 5-10 in San Diego, California.

"We are excited to present our findings on IPH45 at this year's AACR. IPH45 is a cutting-edge ADC that delivers a topoisomerase I inhibitor to tumors expressing Nectin-4. Our studies demonstrate that IPH45 effectively inhibits tumor growth both in vitro and in vivo, and it exhibits a favorable safety profile in preclinical studies," stated Prof. Eric Vivier, DVM, PhD, Chief Scientific Officer at Innate Pharma. "These promising results underscore the potential of IPH45 and reflect our dedication to pioneering the next wave of cancer treatments through advanced antibody engineering. Based on these encouraging data, we are eagerly advancing IPH45 towards clinical trials."

Details of the presentation

• Preclinical characterization of IPH45, a novel topoisomerase I inhibitor ADC targeting Nectin‑4 for the treatment of Nectin-4 expressing tumors
  Abstract Presentation Number: 6582
  Session Type: Minisymposium
  Session Category: Experimental and Molecular Therapeutics
  Session Title: Drug Discovery 2: New Therapies
  Session Date/Time: Tuesday Apr 9, 2024 2:30 PM - 4:30 PM

More information can be found on the AACR website.

About IPH45

Nectin-4 is a cell membrane adhesion protein overexpressed in several solid tumors, including urothelial, breast, lung, ovarian, and pancreatic cancers, with limited expression in normal tissues. IPH45 is a novel topoisomerase I inhibitor Antibody Drug Conjugate (ADC) targeting Nectin-4. In non-clinical models, IPH45 is well tolerated and shows anti-tumor efficacy in vitro and in vivo. IPH45 is progressing towards First in Human Studies.

About Innate Pharma

Innate Pharma S.A. is a global, clinical-stage biotechnology company developing immunotherapies for cancer patients. Its innovative approach aims to harness the innate immune system through therapeutic antibodies and its ANKET (Antibody-based NK cell Engager Therapeutics) proprietary platform.

Innate’s portfolio includes lead proprietary program lacutamab, developed in advanced form of cutaneous T cell lymphomas and peripheral T cell lymphomas, monalizumab developed with AstraZeneca in non-small cell lung cancer, as well as ANKET multi-specific NK cell engagers to address multiple tumor types.