Orgenesis Provides Update Regarding AIP Cell-Based Therapy for Type 1 Diabetes, MaSTherCell Cell Manufacturing Subsidiary and Overall Financial Condition

GERMANTOWN, MD--(Marketwired - Mar 8, 2017) - Orgenesis Inc. (OTCQB: ORGS), a vertically-integrated biopharmaceutical company with expertise and unique experience in cell therapy development and manufacturing, today provided a business update from the Company's CEO, Vered Caplan. The Company also reported that revenue for the fiscal year ending November 30, 2016 increased 115% to $6.4 million from $3.0 million in fiscal 2015 due to growth of MaSTherCell, the Company's cell therapy manufacturing subsidiary.

Vered Caplan, CEO of Orgenesis, commented, "2016 was a transformative year for the Company and we continue to be very encouraged by the outlook for the business. A summary of our accomplishments are as follows:

• Through our Israeli subsidiary, we continue to advance our unique cell-based therapy, the Autologous Insulin Producing ("AIP") cells, into clinical development. AIP cells utilize the technology of 'cellular transdifferentiation' to transform an autologous adult liver cell into a fully functional and physiologically glucose-responsive insulin-producing cell. Because the AIP cells are autologous, this benefit should be achieved and maintained without the need for concomitant immunosuppressive therapy. Diabetes is one of the most challenging health problems globally, incurring staggering health, societal, and economic impact. We believe our platform technology will provide Type 1 diabetes patients with long-term insulin independence, which would transform the lives of patients suffering from this debilitating disease."
  
  
• Through our wholly-owned CDMO subsidiary, MaSTherCell, we are establishing a global reputation as a premier service provider in the regenerative medicine industry. While academic and industrial research has greatly advanced scientific development in the sector, industrialization and manufacturing expertise remains insufficient. We plan to fill this gap by providing two types of services to our customers: (i) process and assay development and optimization services; and (ii) current Good Manufacturing Practices (cGMP) contract manufacturing services. In 2016, MaSTherCell entered agreements with a number of the leading pharmaceutical and biotech companies, as well as research institutions and hospitals involved in cutting-edge cell therapy companies. As the industry continues to mature and a growing number of cell therapy companies approach commercialization, we believe that MaSTherCell is well positioned to serve as an external manufacturing source for a wide array of cell therapy companies."