Oncolytics Biotech(R) Announces Poster Presentation at the 2018 Gastrointestinal Cancers Symposium Sponsored by ASCO in Patients with Relapsed Metastatic Adenocarcinoma of the Pancreas

CALGARY, AB and SAN DIEGO, CA--(Marketwired - January 19, 2018) - Oncolytics Biotech^® Inc. (TSX: ONC) (OTCQX: ONCYF), a biotech company developing REOLYSIN^®, also known as pelareorep, an intravenously delivered immuno-oncolytic virus that activates the innate and adaptive immune systems to turn "cold" tumors "hot", today announced that the poster presentation highlighting results from the REO 024 study was presented at the 2018 Gastrointestinal Cancers Symposium sponsored by ASCO. The conference runs January 18 - 20, 2018, in San Francisco.

"This phase 1b study combining pelareorep and Keytruda in second line pancreatic patients, was designed to evaluate safety and tolerability," said Dr. Matt Coffey, President and CEO of Oncolytics Biotech. "This poster presentation is very important, not only because it also demonstrated a signal of activity, but because it didn't appear to increase immune related toxicity. Efficacy, in combination with checkpoint inhibitors, now needs to be evaluated in a larger phase two study to further validate pelareorep's ability to provide a meaningful increase in overall survival with these agents."

The poster, outlining pelareorep tested in combination with chemo and pembrolizumab (KEYTRUDA^®) in eleven patients with relapsed metastatic adenocarcinoma of the pancreas, provides updates on data submitted within the abstract, including the number of evaluable patients and partial response data. The poster outlines six efficacy evaluable patients, including one that had partial response lasting 17.4 months and two with stable disease of 126 days and 277 days. The poster also demonstrates manageable safety profiles and antitumor activity in previously treated patients with relapsed metastatic pancreatic adenocarcinoma. Furthermore, on-treatment biopsies showed selective reovirus infection and caspase activation in cancer cells and infiltration by CD8 T-cells, demonstrating the virus's ability to induce cell death and a pro-inflammatory phenotype in treated tumors. Further evaluation of anti-tumor activity of pelareorep and an anti-PD-1 antibody plus or minus chemotherapy combinations is planned.