Clover Biopharmaceuticals Announces Positive Phase 1 Data for its Adjuvanted S-Trimer COVID-19 Vaccine Candidates - Seite 2

Joshua Liang, Chief Executive Officer of Clover Biopharmaceuticals, said, “With positive results from our Phase 1 clinical trial demonstrating strong neutralizing immune responses and favorable safety profiles, we look forward to moving our COVID-19 vaccines into the final stages of clinical development. Combined with our ability to potentially produce more than one billion doses of antigen annually and the stability of our vaccines under standard refrigeration conditions, our adjuvanted COVID-19 S-Trimer vaccines are positioned to be well-suited for worldwide distribution. We and our collaborators are steadfast in our commitment to the development of safe, effective and accessible COVID-19 vaccines for the global population.”

Thomas Breuer, Chief Medical Officer of GSK Vaccines, commented, “We are delighted by the promising Phase 1 clinical data underscoring the robust and rapid immune response elicited by GSK’s pandemic adjuvant system combined with Clover’s antigen - in both, adults and older adults and are looking forward to demonstrate the public health value in the upcoming efficacy trial. These results – in addition to results from the combination of our adjuvant with other COVID-19 vaccine technologies - show GSK’s commitment to provide scalable solutions to tackle the pandemic around the globe.”

Rob Janssen, Chief Medical Officer of Dynavax, commented, “We are pleased with the strong immune responses and an outstanding safety profile of Clover’s S-Trimer vaccine adjuvanted with Dynavax’s advanced CpG 1018 adjuvant plus alum. We are encouraged by the high level of neutralizing antibodies in combination with the strong Th1 response which we believe could play an important role in controlling infection. We are proud to be partnered with Clover in our endeavors to develop a safe and effective COVID-19 vaccine that will be readily accessible around the world to combat this ongoing pandemic.”

The Phase 1 clinical trial was funded by the Coalition for Epidemic Preparedness Innovations (CEPI). “This is very promising Phase 1 data which warrants further clinical development of Clover’s S-Trimer vaccine candidate, “ Dr. Richard Hatchett, Chief Executive Officer of CEPI commented, “This vaccine candidate has the potential to be manufactured at scale and stored in a regular refrigerator which makes it suitable for use around the globe, including in low-resource settings. Through our partnership with Clover we hope to make hundreds of millions of doses of this vaccine globally accessible through COVAX, if it is proven to be safe and effective.”