TILT Biotherapeutics advances cancer immunotherapy clinical trial achieving primary end point in the first cohort - Seite 2
The company has received approval in Denmark to extend this trial for up to two years to demonstrate long term survival benefit. As part of this, the company will be analyzing secondary end points for TILT-123 including response rate, overall survival, progression free survival, and immune response against the tumor, its persistence and shedding.
The heart of TILT's approach revolves around the use of armed oncolytic adenoviruses, using cytokines to boost the patient's immune response to better enable it to find and destroy cancer cells. The TUNINTIL trial's primary objective is to evaluate the safety of TILT-123 and is designed to also deliver insights about the behavior of TILT-123 in humans, such as systemic tumor transduction following intravenous delivery and virus replication in the tumor, as well as immunological responses.
(1) Link to the 'TUNINTIL' clinical trial details: https://clinicaltrials.gov/ct2/show/NCT04217473?term=TILT-123&draw=2&rank=1
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TILT Biotherapeutics
CBO Aino Kalervo
aino@tiltbio.com
Scius Communications
Katja Stout
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About TILT Biotherapeutics
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TILT Biotherapeutics is a clinical-stage biotechnology company developing cancer therapeutics based on its proprietary oncolytic adenoviruses armed with molecules including cytokines that can stimulate, or suppress, T cells. The company's patented TILT technology, which can be delivered locally and systemically, modifies the tumor microenvironment and eliminates its ability to suppress immune responses to cancer, thereby enhancing T-cell therapies such as checkpoint inhibitors and CAR T therapies.
TILT's lead asset, TILT-123, is a 5/3 chimeric serotype adenovirus armed with two human cytokines; TNF alpha and IL-2. TILT-123 has demonstrated a 100% response rate in pre-clinical cancer models in vivo, and it is currently in Phase 1 clinical trials.
The Company's pioneering approach has been recognised by industry leaders including Germany's Merck KGaA and the USA's Pfizer, who are collaborating to investigate TILT-123's therapeutic effect in combination with the PD-L1 inhibitor, Avelumab (Bavencio), in clinical trials. In 2019, TILT established an additional partnership with Biotheus, a privately held Chinese company based in Zhuhai, Guangdong, China, for the development and commercialization of TILT's proprietary oncolytic virus TILT-123 in Greater China.
Based in Helsinki, Finland, the company was established in 2013 as a spin-out from the University of Helsinki. It has funding from Lifeline Ventures, angel investors, Business Finland, and the European Innovation Council (EIC).