Core One Labs' Akome Achieves Another Milestone in Development of its Psychedelic Drug Formulas and Announces Positive Results from Neuro-Pharmacokinetics Studies

VANCOUVER, BC / ACCESSWIRE / August 19, 2022 / Core One Labs Inc. (CSE:COOL), (OTCQB:CLABF), (Frankfurt:LD6, WKN:A3CSSU) (the "Company" or "Core One") is pleased to announce that its wholly owned subsidiary Akome Biotech Ltd. ("Akome") through its formalized research agreement with Fundación Medina in Granada, Spain ("Fundación Medina") has received very encouraging results from pharmacokinetics studies currently underway. The study results represent another significant milestone in the Company's pre-clinical development of its psychedelic based bioactive compounds designed to target Major Depressive Disorder ("Depression"), Stroke, Parkinson's Disease ("PD") and Alzheimer's Disease ("AD"), and warrant moving the formulations further along the development pipeline.

Pharmacokinetics studies the absorption, distribution, metabolism and excretion ("ADME") of drugs in humans, and also tests toxic effects ("TOX") of the drug candidate on body systems or organs. These studies are paramount in drug discovery and development as they de-risk drug candidate compounds and ultimately improve their productivity. When compounds are being developed for the treatment of neurologic and mental health disorders, it is also critical to determine the tissue concentration and behaviour in the brain of the candidate compounds, which is referred to as neuro-pharmacokinetics.

The very encouraging results from ADME/TOX neuro-pharmacokinetics studies, conducted by Fundación Medina, show that Akome's bioactive compounds tested in controlled settings are performing very well, increasing the level of confidence scientists require for understanding the potential efficacy of Akome's drug candidates, and moving our drug discovery process further along the development continuum towards regulatory approval.

"Core One's scientists and research partners are achieving positive results at every stage of our pre-clinical drug trials, and we are thrilled with the progress that Akome is making in moving its psychedelic-based formulations along the development pipeline," stated Joel Shacker, Core One Labs CEO.

"The results presented today, combined with the positive bioassay results presented by the Company in April , demonstrate the significant potential our drug formulations hold. I am confident scientists at Akome, along with their research partners will continue to deliver strong results based on their track record of successes," he further added.