Ensysce Biosciences Discusses TAAP and MPAR(R) Applications and OncoZenge Partnership with The Stock Day Podcast

PHOENIX, AZ / ACCESSWIRE / December 11, 2023 / The Stock Day Podcast welcomed Ensysce Biosciences (NASDAQ:ENSC) ("the Company"), a clinical-stage company using its proprietary technology platforms to develop safer prescription drugs.CEO of the Company, Dr. Lynn Kirkpatrick, joined Stock Day host Matthew Dunehoo.

Dunehoo began the interview by asking about the Company's background and current projects. "Ensysce Biosciences is a clinical stage company using two highly novel technology platforms, TAAP and MPAR, while applying these to known therapies to improve both drug safety and drug performance," explained Dr. Kirkpatrick. "We have applied TAAP and MPAR to a number of different drug classes but we are focused initially on the opioid-classic medications, in order to stem the crisis that as we know has resulted in thousands of deaths over the last decade."

"By using known therapies, we believe we can develop new drugs more quickly and at reduced costs, while expanding our product pipeline across many indications," continued Dr. Kirkpatrick. "We have developed our lead product, PF614, which is an oxycodone TAAP-pro drug and all of our clinical trials have shown that it works exactly how it is designed," she explained, adding that the drug features an extended release design and has been proven pain relief for a 12-hour period.

"We chemically modify a drug, in this case oxycodone, to make it inactive unless swallowed," said Dr. Kirkpatrick. "It uses the body's own digestive enzyme to start an activation process releasing oxycodone for absorption and pain relief," she said. "When the drug is inactive unless swallowed, it removes the ability to administer the drug through inhalation, snorting, or injection to remove those pieces of abuse potential," said Dr. Kirkpatrick. "It also gives us a true twice a day product."

"With MPAR, Multi-Pill Abuse Resistance, this takes the protection one step further," continued Dr. Kirkpatrick, noting that the drug features a digestive enzyme prohibitor. "It blocks the digestive enzyme that is used to release the drug when you have taken too much, and it only kicks in when you take more than the prescribed dose."

"We believe TAAP and MPAR make opioids safer," said Dr. Kirkpatrick. "The beauty of these platforms are that they can be applied to other medications that may have a safety or delivery issue," she said. "It gives us many opportunities in our development platform."

"When do you anticipate Phase III trials and ultimately the potential commercialization for PF614?", asked Dunehoo. "Over the last 18 months we have been working diligently to complete all of the work we need to get to Phase III," said Dr. Kirkpatrick. "We are poised for Phase III and we have a meeting scheduled with the FDA in January to discuss our plans, which is called an end of Phase II meeting," she explained. "We believe we are on track with our plans to start conducting Phase III trials in 2024, while still filing our NDA in late 2025, and commercialize at that point after review."