Idorsia presents at the J.P. Morgan Healthcare Conference – Adapting Idorsia for sustainable value creation

Ad hoc announcement pursuant to Art. 53 LR

• CEO, Jean-Paul Clozel, to update on how Idorsia is being adapted for sustainable value creation
• The company is focused on extending the cash runway beyond the current estimate of early April 2024, through various avenues, including potential out-licensing deals
• Postponement of the publication of Full-Year 2023 Financial Results and the subsequent Annual General Meeting of Shareholders

Allschwil, Switzerland – January 10, 2024
Idorsia Ltd (SIX: IDIA) today announced that Jean-Paul Clozel, Chief Executive Officer of Idorsia, will present at the J.P. Morgan Healthcare Conference on January 10, 2024, at 10:30 PST / 19:30 CET. The conference will take place at the Westin St. Francis hotel in San Francisco, USA.

Jean-Paul will describe how Idorsia is being adapted for sustainable value creation. The presentation will cover the progress of QUVIVIQ (daridorexant) in the US and Europe, and the clinical data included in the new drug application for aprocitentan with the US Food and Drug Administration (FDA) which is currently under review. He will also present other unencumbered assets that provide the company with strategic flexibility and several avenues to explore potential fundraising. Follow this link to access the audio stream and find the presentation available here.

Jean-Paul Clozel MD and Chief Executive Officer of Idorsia commented:
“Creating a sustainable pharma company requires scientific innovation and substantial investment. We have demonstrated our ability to innovate and bring new drugs to the market and have a portfolio of innovative products, however, we have limited financing, so we need to prioritize activities that offer the maximum return in the near term. We estimate the current cash reserves to last to early April 2024, we therefore plan to extend the cash runway through various avenues, including potential out-license deals.”

Expected highlights in 2024

• Secure additional funding to extend the cash runway
• Expand access and availability of QUVIVIQ (daridorexant) in the US, Canada and across Europe
• Achieve FDA decision for the NDA for aprocitentan in resistant hypertension
• Achieve EMA decision for the MAA for aprocitentan in resistant hypertension

Jean-Paul commented on the portfolio:
“More than 11 million QUVIVIQ tablets have been dispensed to help patients achieve better nights and days. We have made great progress with access and availability in our key markets, and I expect to see that translating into income in 2024. I also expect aprocitentan – the first antihypertensive working on a new pathway for 30 years – to become available for treated patients whose hypertension remains uncontrolled. Discussions with health authorities are going well and I’m confident that the label will reflect the outstanding results we’ve seen for these high-risk patients. We also intend to progress the two global Phase 3 programs with selatogrel and cenerimod which have the potential to transform treatment in their target indications.”