Gossamer Bio Announces Publication of TORREY Phase 2 Results in the Lancet Respiratory Medicine

Gossamer Bio, Inc. (Nasdaq: GOSS), a clinical-stage biopharmaceutical company focused on the development and commercialization of seralutinib for the treatment of pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease (PH-ILD), today announced the publication of its TORREY Phase 2 study manuscript in the Lancet Respiratory Medicine journal. The paper, titled "Seralutinib in Adults with Pulmonary Arterial Hypertension (TORREY): A Randomized, Double-blind, Placebo-controlled Phase 2 Trial," details the study's significant findings in advancing the treatment of PAH.

TORREY was a Phase 2, randomized, multicenter, multinational, double-blind, placebo-controlled study, evaluating the efficacy and safety of Gossamer’s novel therapy, seralutinib, in patients with PAH, a progressive condition that can lead to right heart failure and significantly reduces quality of life. 86 patients were randomized to receive either seralutinib or placebo by dry powder inhaler twice daily for 24 weeks. The results demonstrated a statistically significant improvement for seralutinib compared to placebo in the primary endpoint, reduction of pulmonary vascular resistance (PVR), and other important measures of disease, including measures of right heart structure and function.

Following the successful completion of TORREY, seralutinib was progressed into the ongoing global, registrational Phase 3 PROSERA Study for the treatment of PAH in WHO Functional Class II and III PAH patients (PROSERA). Details about PROSERA can be found here: https://clinicaltrials.gov/ct2/show/NCT05934526

"The publication of the TORREY results in Lancet Respiratory Medicine represents a significant milestone in our ongoing commitment to addressing unmet medical needs for patients with pulmonary hypertension,” said Faheem Hasnain, CEO, Co-founder, and Chairman of Gossamer Bio. “The results detailed in the publication help to form the basis of our excitement for the potential of seralutinib to improve the lives of patients living with this progressive disease."

The manuscript can be accessed at https://doi.org/10.1016/S2213-2600(24)00072-9 and will be featured in an upcoming print version of the journal.

About Gossamer Bio

Gossamer Bio is a clinical-stage biopharmaceutical company focused on the development and commercialization of seralutinib for the treatment of pulmonary hypertension. Its goal is to be an industry leader in, and to enhance the lives of patients living with, pulmonary hypertension.