OSE Immunotherapeutics Announces First Peer-Reviewed Publication in "Science Advances" on OSE-230, its Novel Monoclonal Antibody Agonist Therapy Triggering Resolution of Chronic Inflammation - Seite 2

Alexis Peyroles, Chief Executive Officer of OSE Immunotherapeutics, adds: “OSE-230 is an additional program that positions OSE as a true leader in innovation and discovery of new pathways. Based on the strong potential of OSE-230, we look forward to initiating an ambitious development plan to address the numerous patients’ need for disruptive innovations to manage complex inflammatory diseases.”

This research was the result of a productive collaboration between the OSE R&D team and scientific partners at Ambiotis, a French Contract Research Organization specialized in the active resolution of inflammation, MAbSilico, a deep technology innovative French TechBio specialized in Artificial Intelligence and the CRTI (Center for Research in Transplantation and Immunology, UMR1064, INSERM, Nantes University based at the University Hospital of Nantes).

⁽¹⁾ Agonist anti-ChemR23 mAb reduces tissue neutrophil 1 accumulation and triggers chronic inflammation resolution
Trilleaud C., Gauttier V., Biteau K., Girault I., Belarif L., Mary C., Pengam S., Teppaz G., Thepenier V., Danger R., Robert-Siegwald G., Néel M., Bruneau S., Glemain A., Néel A., Poupon A., Mosnier JF., Chêne G., Dubourdeau M., Blancho G., Vanhove B., Poirier N.

ABOUT OSE Immunotherapeutics
OSE Immunotherapeutics is an integrated biotechnology company focused on developing and partnering therapies to control the immune system for immuno-oncology and autoimmune diseases. The company’s immunology research and development platform is focused on three areas: T-cell-based vaccination, Immuno-Oncology (focus on myeloid targets), Auto-immunity & Inflammation. Its balanced first-in-class clinical and preclinical portfolio has a diversified risk profile:

Vaccine platform

• Tedopi (innovative combination of neoepitopes): the company’s most advanced product; positive results for Step-1 of the Phase 3 trial (Atalante 1) in Non-Small Cell Lung Cancer post checkpoint inhibitor failure.
  In Phase 2 in pancreatic cancer (TEDOPaM, sponsor GERCOR)
  In Phase 2 in ovary cancer (TEDOVA, sponsor ARCAGY-GINECO)
  Due to the COVID-19 crisis, accrual of new patients in TEDOPaM should restart in 2021.
• CoVepiT: a prophylactic second-generation vaccine against COVID-19, developed using SARS-CoV-2 optimized epitopes against multi variants. Positive preclinical and human ex vivo results in August 2020. In clinical Phase 1.