Nicox Estimates Potential Annual Global Net Sales for NCX 470 of over $300 million

Press Release

Nicox Estimates Potential Annual Global Net Sales for NCX 470 of over $300 million

NCX 470 therapeutic profile positively received among U.S. eye care professionals in a market survey conducted with a leading, independent research agency

• Potential annual global net sales for NCX 470 estimated to reach at least $300 million within 8 years from the date of launches in U.S. and China
• Nicox currently seeking U.S. and Japanese commercial partners for NCX 470

July 10, 2023 – release at 7:30 am CET
Sophia Antipolis, France



Nicox SA (Euronext Growth Paris: FR0013018124, ALCOX), an international ophthalmology company, today provided details of a U.S. market survey evaluating the commercial potential of NCX 470, a nitric oxide (NO)-donating bimatoprost, in development for the lowering of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension and estimated potential global annual net sales for NCX 470.



“We recently conducted a market survey with a leading, independent research agency in the United States which confirmed the interest from ophthalmologists and optometrists in the potential use of NCX 470 as a therapeutic option for patients who do not reach their target intraocular pressure. The research also informed our potential pricing and reimbursement strategies, which we have factored into our assessment of the potential sales.” said Andreas Segerros, CEO of Nicox. “Based on this data, and insights from our Chinese and Southeast Asian partner, Ocumension Therapeutics, together with estimates of sales in other territories, we believe that annual global net sales of NCX 470 could be over $300 million within 8 years of the date of launches in the U.S. and China.”

About NCX 470



NCX 470, a novel NO-donating bimatoprost eye drop, is currently in Phase 3 clinical development for the lowering of IOP in patients with open-angle glaucoma or ocular hypertension. Results of Mont Blanc, the first of the two Phase 3 clinical trials, were announced in October 2022. The second Phase 3 clinical trial, Denali, is currently ongoing, and the results are expected¹ in 2025. Mont Blanc and Denali have been designed to fulfill the regulatory requirements for safety and efficacy Phase 3 trials to support NDA submissions in both the U.S. and in China, where NCX 470 is exclusively licensed to Ocumension Therapeutics.