Omega Therapeutics to Host Conference Call to Discuss Preliminary Clinical Data for OTX-2002 from Ongoing MYCHELANGELO I Trial on September 26

CAMBRIDGE, Mass., Sept. 25, 2023 (GLOBE NEWSWIRE) -- Omega Therapeutics, Inc. (Nasdaq: OMGA) (“Omega”), a clinical-stage biotechnology company pioneering the development of a new class of programmable epigenomic mRNA medicines, today announced that management will host a conference call and webcast to discuss preliminary clinical data from the ongoing Phase 1/2 MYCHELANGELO I trial of OTX-2002 on Tuesday, September 26, 2023, at 8:00 a.m. ET.

The webcast will feature members of Omega’s leadership team as well as a moderated discussion with Gerard Evan, Ph.D., Principal Group Leader of the Francis Crick Institute in London and Professor of Cancer Biology, King's College London.

The live webcast can be accessed under “News & Events” on the investors section of Omega’s website at https://ir.omegatherapeutics.com/news-events/event-calendar. To participate in the live call, please register using this link. It is recommended that participants register at least 15 minutes in advance of the call. Once registered, participants will be informed of the dial-in numbers including PIN. The archived webcast will be available on Omega’s website for approximately 90 days following the event.

About OTX-2002

OTX-2002 is an mRNA therapeutic delivered via lipid nanoparticles (LNPs) designed to downregulate MYC expression pre-transcriptionally through epigenetic modulation while potentially overcoming MYC autoregulation. MYC is a master transcription factor that regulates cell proliferation, differentiation and apoptosis and plays a significant role in more than 50% of all human cancers. OTX-2002 has demonstrated the ability to control MYC expression pre-transcriptionally in multiple preclinical studies, including the successful downregulation of MYC in non-human primates. Additionally, OTX-2002 has shown robust anti-tumor activity alone and in combination with standard of care therapies in vivo in multiple preclinical models of HCC. Currently, OTX-2002 is being evaluated as a potential treatment for HCC and other solid tumors associated with MYC. 

About MYCHELANGELO I

MYCHELANGELO I (NCT05497453) is a Phase 1/2 open label trial evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of OTX-2002 as a monotherapy (Part 1) and in combination with standard of care therapies (Part 2) in patients with relapsed or refractory HCC and other solid tumor types known for association with the MYC oncogene. The study is currently enrolling patients in the U.S. and Asia.