Notable Labs Announces JCO Precision Oncology Publication Demonstrating PPMP Potential to Identify Novel Drug Combinations in JMML

– Article Published in November 9th Issue of ASCO’s Journal of Clinical Oncology Precision Oncology (JCO PO) –

– Results highlight PPMP as a tool for identifying most promising drug combinations for patients in high unmet medical needs, including JMML –

FOSTER CITY, Calif., Nov. 09, 2023 (GLOBE NEWSWIRE) -- Notable Labs, Inc. (“Notable”) (Nasdaq: NTBL), a clinical stage therapeutic platform company developing predictive precision medicines for cancer patients, today announced the publication of data from an ex vivo study demonstrating the potential for its Predictive Precision Medicine Platform (PPMP) to identify more effective pre-hematopoietic stem cell transplantation (pre-HSCT) regimens for the treatment of juvenile myelomonocytic leukemia (JMML) in the November 9th Issue of the American Society of Clinical Oncology (ASCO) Journal JCO Precision Oncology. Part of this data was recently presented at the European Hematology Association (EHA) Hybrid Congress held in Frankfurt, Germany on June 8 – 15, 2023. Details of that presentation can be found on the Company’s website at https://notablelabs.com/.

JMML is a rare, aggressive pediatric malignancy for which curative treatment is restricted to hematopoietic stem cell transplantation. Pre-HSCT therapies, i.e., therapies prior to transplantation, include moderately intensive chemotherapy (particularly fludarabine and cytarabine in combination (FLA)) and azacytidine (AZA) monotherapy. Unfortunately, in many cases, neither FLA nor AZA effectively eliminates the malignant cells and patients proceed to transplant with active disease.

Applying its proprietary PPMP technology to blood or bone marrow samples from JMML patients, Notable screened 130 drug combinations and discovered that 27 of these combinations (26 dual-, 1 triple-combination) were more effective ex vivo than the components of these combinations tested individually. Of particular interest, investigators found that tretinoin (all-trans retinoic acid), a drug used as a standard-of-care agent in acute promyelocytic leukemia (APL), specifically enhanced the ex vivo effects of FLA and AZA. In addition to lowering the numbers of cells surviving FLA or AZA treatment, tretinoin, interestingly, also induced the cell surface expression of CD38, suggesting a potential rationale for use of CD38-targeting agents to further enhance the envisioned treatment effect. By identifying a superior combination effect with tretinoin, this research study identified potentially more effective pre-HCST regimens than those currently in use in JMML.