Manuscript Published on Multiorgan Failure Patients Treated with SeaStar Medical’s Selective Cytopheretic Device Who Achieved Transplant Eligibility

SCD’s ability to improve clinical status of four critically ill pediatric and adult patients across multiple clinical conditions published in Transplantation Direct

DENVER, May 22, 2024 (GLOBE NEWSWIRE) -- SeaStar Medical Holding Corporation (Nasdaq: ICU), a commercial-stage medical device company developing proprietary solutions to reduce the consequences of hyperinflammation on vital organs, announces the publication of a manuscript citing four case studies in which critically ill patients between the ages of 22 months and 71 years with multiorgan failure who were treated with the Selective Cytopheretic Device (SCD) successfully stabilized and improved their clinical status prior to stem cell or liver transplant, or left ventricular assist device implantation. The abstract was published in peer-reviewed Transplantation Direct, which is available here.

Titled “Increasing Eligibility to Transplant Through the Selective Cytopheretic Device (SCD): A Review of Case Reports Across Multiple Clinical Conditions,” the manuscript by S. Iyer, C. Pino, L. Yessayan, S. Goldstein, M. Weir, A. Westover, D. Catanzaro, K. Chung and H.D. Humes notes that a stable, minimum physiological health status is required for patients to qualify for transplant or artificial organ to ensure the recipient has sufficient reserve to survive the perioperative transplant period. Excessive systemic inflammation or hyperinflammation can prevent the body from returning to immune homeostasis and toward organ recovery, potentially delaying or prohibiting a needed transplantation. The SCD is an extracorporeal device that is designed to abate hyperinflammation by selectively targeting and transitioning proinflammatory monocytes to a reparative state regardless of the underlying clinical conditions.

“SCD therapeutic treatment was used to reduce the consequences of excessive inflammation in these four patients with different etiologies yet all with high levels of organ dysfunction. In each case, the SCD was able to improve the patient’s clinical status or extend the duration of improvement prior to transplantation,” said Sai P. Iyer, PhD, SeaStar Medical Vice President, Medical Affairs and Clinical Development. “The SCD was well tolerated, with no serious device-related adverse events, infections or signs of immuno-depletion observed in any patient. Although these are initial pilot cases, the favorable results form the basis for further investigation in additional clinical studies.”