Cyclo Therapeutics Enters Research and Collaboration Agreement with Wits Commercial Enterprise (Pty) Ltd to Explore Potential Applications of Trappsol Cyclo to Expand Pipeline

Cyclo Therapeutics, Inc. (Nasdaq: CYTH) (“Cyclo Therapeutics” or the “Company”), a late clinical stage biotechnology company dedicated to developing life-changing medicines through science and innovation for patients and families living with diseases, today announced that it has entered into a research and collaboration agreement with the University of the Witwatersrand, Johannesburg (Wits) represented by Wits Commercial Enterprise (Pty) Ltd, a wholly owned subsidiary of the University whose mandate is to protect and manage the University’s intellectual property. Under the terms of the collaboration agreement, Wits and Cyclo Therapeutics plan to develop and coordinate projects or activities to further scientific advancement of the Company’s proprietary platform technology, Trappsol Cyclo.

N. Scott Fine, Chief Executive Officer of Cyclo Therapeutics commented, “We have established proof-of-concept and compelling data to-date with Trappsol Cyclo and currently have a Phase 3 study in Niemann-Pick Disease Type C underway, and are preparing to advance our Phase 2 study in Alzheimer’s disease. This growing body of encouraging data, combined with our unique mechanism of action facilitated an exciting dialogue with Wits and warrants pursuing together further applications of our technology in additional indications. This collaboration is an important strategic step forward in understanding the potential and expected broad utility of our validated platform technology. We believe working with Wits, a world-renowned teaching, research and development institution, will enable us to explore the depth and breadth of our pipeline opportunities with Trappsol Cyclo as well as bolster our growing intellectual property estate. We look forward to working with the Wits team to advance this technology and provide what we believe will be a solid foundation to fuel a robust pipeline.”

Prof Mandeep Kaur of Wits’ School of Molecular and Cell Biology commented, “The collaboration with Cyclo Therapeutics is an exciting milestone in our endeavors to develop innovative and groundbreaking treatment for various disease indications based on our proof-of-concept studies concluded in the past few years. This complementarity of skills and experience will facilitate new knowledge generation for the benefit of science and humanity, signifying the true spirit of Ubuntu. We believe that our collaboration with a progressive company like Cyclo Therapeutics will enhance our capability to explore complex disease related pathways while translating impactful research to clinics in the future. We are delighted to have Cyclo Therapeutics on-board during our therapeutics discovery and innovation journey.”