Big Developments Set to be Unveiled at This Year's San Antonio Breast Cancer Symposium (SABCS)

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VANCOUVER, British Colombia, Nov. 30, 2022 /PRNewswire/ -- USA News Group  -  A new study has revealed that women diagnosed with benign breast disease through screening have an almost double risk of acquiring breast cancer. The findings come ahead of this year's San Antonio Breast Cancer Symposium (SABCS), known as one of the largest breast cancer symposiums in the world. This year's SABCS is already shaping up to contain some big developments, including data and presentations from biotech companies such as Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC), Eli Lilly and Company (NYSE: LLY), NeoGenomics, Inc. (NASDAQ: NEO), Zymeworks Inc. (NYSE: ZYME), and G1 Therapeutics, Inc. (NASDAQ: GTHX).

Ahead of the SABCS, which is scheduled for December 6-10, 2022, analysts at ReportLinker are projecting that the Global Breast Cancer Therapeutics Market is expected to grow by US$13.85 billion during 2022-2026, accelerating at a CAGR of 8.95% during the forecast period.

Set to present two new abstracts at the SABCS is Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC) through a pair of poster presentations, including interim results from a bridging clinical trial being conducted with partners Adlai Nortye, to evaluate Oncolytics' flagship asset pelareorep in combination with paclitaxel in patients with advanced or metastatic HR+/HER2- breast cancer in one poster. The second poster will include data from a collaboration with SOLTI-Innovative Cancer Research from the AWARE-1 window-of-opportunity study in early-stage breast cancer patients. Full texts of the abstracts are available on the SABCS website.

Data published in the SABCS abstract indicates that pelareorep in combination with paclitaxel was safe, well tolerated, and showed anti-tumor activity in Adlai Nortye's single-arm bridging clinical trial in Chinese patients with advanced or metastatic HR+/HER2- breast cancer. As of the abstract's cut-off date, 10 patients were treated, with 4 achieving a partial response (PR) (2 confirmed, 2 unconfirmed), and 5 showing stable disease (SD).

This bridging trial is designed to accelerate Adlai Nortye's development of pelareorep in China by allowing future regulatory submissions to include data from Oncolytics' North American metastatic breast cancer trials, IND-213 and BRACELET-1.

Results from IND-213 showed a statistically significant near doubling of median overall survival in HR+/HER2- breast cancer patients treated with pelareorep plus paclitaxel compared to those treated with paclitaxel monotherapy. BRACELET-1 remains ongoing, with a readout on overall response rate, progression-free survival, and evolving overall survival data from the randomized phase 2 trial expected in the first half of 2023.