Affimed Announces an ASCO Breakthrough Poster Presentation with Clinical Data of AFM24 in Combination with NKGen Biotech’s SNK01 NK Cells

• Stable disease was observed in three out of seven heavily pretreated patients
• No dose-limiting toxicities or unexpected toxicities were observed

HEIDELBERG, Germany, July 31, 2023 (GLOBE NEWSWIRE) -- Affimed N.V. (Nasdaq: AFMD) (“Affimed”, or the “Company”), a clinical-stage immuno-oncology company committed to giving patients back their innate ability to fight cancer, today announced that an abstract with clinical trial results of its innate cell engager (ICE) AFM24 in combination with NKGen Biotech’s SNK01 (autologous non-genetically modified NK cells), has been accepted for a poster presentation at the ASCO Breakthrough conference from 3-5 August 2023 in Yokohama, Japan. The presentation includes dose escalation phase data on safety and efficacy of the phase 1 study in patients with advanced or metastatic EGFR-expressing solid tumors (NCT05099549).

As of June 2023, seven patients with a mean number of five prior therapies received the combination of AFM24 and SNK01. No unexpected or dose-limiting toxicities were observed, and the PK properties were similar to AFM24 monotherapy. The best objective response was stable disease in three out of the seven patients, including patients with heavily pretreated microsatellite stable colorectal cancer (MSS CRC).

“The poster at ASCO Breakthrough is the first clinical presentation of a bispecific NK cell engager in combination with autologous NK cells,” said Dr. Anthony El-Khoueiry, Associate Director of Clinical Research and Phase I Program Director at the USC Norris Comprehensive Cancer Center and principal investigator of the AFM24 studies. “Our data establish the feasibility of this novel combinatorial approach; the stabilization of disease in heavily pre-treated patients with microsatellite stable colorectal cancer was clinically meaningful.”

“The data presented provide proof-of-concept for the combination of AFM24 with NK cells with good tolerability,” said Dr. Andreas Harstrick, Chief Medical Officer at Affimed. “Despite this, Affimed and NKGen Biotech mutually decided to discontinue the presented study. In line with Affimed’s NK cell combination experience for AFM13, Affimed is currently evaluating the best option to advance AFM24 with an allogeneic off-the-shelf NK cell product.”

Details of the poster presentation are as follows:

Title: AFM24 in combination with autologous NK cells (SNK01) in patients with advanced/metastatic epidermal growth factor receptor (EGFR) expressing solid tumors: Initial results from the Phase 1 dose‑escalation study