Akoya Biosciences Announces Peer-Reviewed Publication Using Ultrahigh-Plex Spatial Phenotyping of Head and Neck Cancer to Identify Distinct Immune and Metabolic Signatures - Seite 2

“Immune checkpoint inhibitors have shown promising results in recurrent and metastatic cases of HNSCC,” said Dr. Arutha Kulasinghe, of The University of Queensland’s Frazer Institute, leader of the Clinical-oMx Lab, and one of the paper’s authors. “Durable treatment results, however, are observed in only 30% of patients, indicating that new biomarkers for stratification of responders and non-responders are needed. The dichotomy of immune activation-induced death and tumor progression we observed in an individual patient’s tissue sample correlated with the partial response seen with ICI therapy. We believe that the approach outlined in this study will pave the way towards a new understanding of tumor microenvironment features associated with response and sensitivity to immune checkpoint inhibitor therapies in head and neck cancer and other solid malignancies.”

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