Dr. Alan Kivitz to Chair XBiotech’s Natrunix Program in Rheumatoid Arthritis - Seite 2

The confusion about interleukin-1 is highlighted by the fact that there is in reality no such substance as interleukin-1! Rather, interleukin-1 actually refers to two separate and distinct molecules—IL-α and IL-1β —each playing unique roles in health and disease. The α and β Interleukin-1 molecules are chemically and physically distinct and under different genetic and post transcriptional regulation. The α and β molecules are thus deployed with disparate temporal and spatial distribution and with unique biological functions. Nonetheless, despite great anticipation for blocking “interleukin-1” activity clinically, no therapeutic besides Natrunix has been developed to specifically and exclusively block IL-1α activity in rheumatology.

Natrunix exclusively and specifically blocks IL-1α. Targeting IL-1α is crucial, since it may be the key interleukin-1 potentiator of pain and inflammation in affected tissues in affected joints. Natrunix is not only unique in how it targets interleukin-1, it also extraordinary because it is a monoclonal antibody (unlike any other marketed therapeutic antibody) derived from a naturally occurring immunoglobulin—identified from a healthy human donor with natural immunity to IL-1α. XBiotech calls Natrunix a True Human Antibody.

About XBiotech

XBiotech is pioneering the discovery and development of targeted antibodies based on its True Human technology. The company’s mission is to discover and commercialize its pipeline of truly natural human antibodies for treating serious diseases such as inflammatory conditions like rheumatology, infectious disease, cardiovascular disease and cancer. XBiotech’s has several candidate products including those that specifically block the activity of interleukin-1 alpha (IL-1α). Cloned from individual donors who possess natural immunity against certain targeted diseases, XBiotech’s pipeline of True Human antibodies are intended to deliver unmatched safety and efficacy. At the Company’s 48-acre campus, located just minutes from downtown Austin, XBiotech has a fully integrated biopharma headquarters, including biological GMP manufacturing facilities, research and QC testing laboratories, quality and clinical operations. For more information, visit www.xbiotech.com.