Celularity Releases CEO Letter to Shareholders - Seite 2

Recently, we took steps to improve our balance sheet and support the growth of our businesses. On Wednesday, 17 January, we announced the closing of two separate financing transactions in which Celularity received combined total gross proceeds of $21 million from a $6 million private placement transaction with our largest single shareholder and a $15 million loan agreement amendment with an existing lender, respectively.

Celularity entered 2024 deeply engaged in the launch of the multi-year Research Collaboration Services Agreement in cell therapy with Regeneron Pharmaceuticals, Inc., which we announced in August. As previously disclosed, the collaboration’s initial focus is research on a targeted allogeneic gamma delta chimeric antigen receptor (CAR) T-cell therapy owned by Regeneron, which is designed to enhance proliferation and potency against solid tumors. This important work will take place at Celularity’s Florham Park headquarters, which incorporates state-of-the-art research and manufacturing infrastructure. I see the Regeneron collaboration as an important validator of our cell therapy expertise, technical infrastructure, and capabilities as well as, I believe, potentially paving the way for future industry collaborations.

Our cell therapy platform includes clinical- and development-stage, off-the-shelf allogeneic cell therapy candidates, some of these employ mechanisms such as recognition of expressed stress antigens thought to potentially target aging processes which contribute to many degenerative disorders and diseases. It is increasingly recognized that the emerging longevity market represents one of the most exciting opportunities in the next decade. Recently, I addressed the HLTH 2023 conference as part of a panel focused on “moonshot thinking” about emergent technologies, treatments, and discoveries to create a healthier future. This aligns with the mission to democratize regenerative medicine that I discussed in the book I coauthored with Tony Robbins and Peter Diamandis and which has been a Celularity lodestar since inception. I believe Celularity’s clinical-stage assets in cell therapy and advanced biomaterials, including placental NK cells, placental pluripotent stem cells and biomaterials like Interfyl can play a role in age-related diseases. Obviously, there is work to be done but the scalability and affordability inherent to our use of the postpartum placenta as a source of newborn cells and biomaterials is what we believe positions Celularity as a regenerative medicine innovator in the emerging science of aging and longevity. I want to stress, our work over the last decade has focused on the biology of placental cells and I believe this has taught us that many of the mechanisms responsible for cancer, serious immunological and degenerative diseases have common denominators which may be addressed with our technology. By one estimate the longevity and anti-senescence therapy market was valued at $26.12 billion in 2022 and is predicted to reach $44.92 billion by the year 2031, growing at a 6.8% CAGR during the forecast period.