CENTOGENE and The Michael J. Fox Foundation Announce Research Project to Validate Genetic Risk Factors of Parkinson’s Disease Using Multiomics - Seite 2

“The Michael J. Fox Foundation is an inspirational leader in Parkinson’s disease research. By working with them, we aim to accelerate research into specific risk factors that may help us better diagnose, understand, and treat this debilitating disease, which affects several million patients worldwide,” said Prof. Peter Bauer, Chief Medical & Genomic Officer at CENTOGENE. “By combining MJFF’s extensive expertise and resources with our deep understanding of the links between rare and neurodegenerative diseases, we will be able to generate pivotal multiomic insights into the role of specific variants in the GBA gene. By providing a more complete understanding of the way that the GBA gene interacts with multiple biological pathways, we can elucidate targets that can be used to develop more precise disease-modifying therapeutics for Parkinson’s patients in the future.”

About GBA-Associated Parkinson’s Disease

GBA-Associated Parkinson's disease (PD) is characterized by specific variants in the GBA (glucosylceramidase beta) gene and has been identified as one of the most common genetic risk factors for PD. Variants in the GBA gene impair the body's ability to break down certain fats, leading to a buildup of harmful substances in nerve cells. This accumulation, as well as potentially other independent consequences of GBA dysfunction, can contribute to the development of PD symptoms, which resemble the motor symptoms of idiopathic PD, such as tremors, stiffness, and bradykinesia. Recognizing the connection between GBA variants and PD is crucial for both diagnosis and potential targeted therapies, emphasizing the importance of ongoing research and clinical investigations in this area, as there's currently no cure for PD.

About CENTOGENE

CENTOGENE’s mission is to provide data-driven, life-changing answers to patients, physicians, and pharma companies for rare and neurodegenerative diseases. We integrate multiomic technologies with the CENTOGENE Biodatabank – providing dimensional analysis to guide the next generation of precision medicine. Our unique approach enables rapid and reliable diagnosis for patients, supports a more precise physician understanding of disease states, and accelerates and de-risks targeted pharma drug discovery, development, and commercialization.