Seer Proteograph Enables Unprecedented Genetic Marker Mapping for Proteogenomics Studies to Advance Drug and Biomarker Discovery - Seite 2

“Dr. Suhre’s study demonstrates the power of Seer’s approach in deconvoluting complex associations between genetic variants and proteins,” said Omid Farokhzad, M.D., Chair & Chief Executive Officer of Seer. “Further collaborative efforts between proteomics and genomics researchers are important to advance the field of multi-omics and critical for unearthing new therapeutic approaches for a wide range of diseases, including cardio and metabolic disorders.”

Seer’s recently launched Proteograph XT Assay Kit for the Proteograph Product Suite, enables unbiased proteomics research at unprecedented speed by more than doubling throughput while maintaining high-resolution insights. Together with next generation mass spectrometers, Proteograph XT offers scientists the capability to detect over 60,000 peptides and over 8,000 proteins in a human plasma study. Further, Seer’s proprietary engineered nanoparticles deliver reliable performance, providing peptide level information that is key to identifying protein variants for proteogenomic studies. Seer's approach provides customers with unparalleled insights into drug response analysis, drug discovery, patient stratifications for clinical studies, and precision medicine.

“There are inherent challenges with analyzing the proteome, particularly in plasma samples, where the high dynamic range makes it difficult to detect less abundant proteins that may be critical to disease biology. The peptide level resolution of the Proteograph platform allowed us to account for potentially confounding epitope effects, traditionally not possible with affinity-based approaches,” commented Serafim Batzoglou, Ph.D., Chief Data Officer of Seer and author on the article. “At Seer, we offer researchers a new method for pQTL mapping and a deeper understanding of proteins and peptides for large-scale proteogenomic studies.”

About Seer

Seer is a life sciences company developing transformative products that open a new gateway to the proteome. Seer’s Proteograph Product Suite is an integrated solution that includes proprietary engineered nanoparticles, consumables, automation instrumentation and software to perform deep, unbiased proteomic analysis at scale in a matter of hours. Seer designed the Proteograph workflow to be efficient and easy to use, leveraging widely adopted laboratory instrumentation to provide a decentralized solution that can be incorporated by nearly any lab. Seer’s Proteograph Product Suite is for research use only and is not intended for diagnostic procedures. For more information, please visit www.seer.bio.