Three Patients with Invasive Fusarium Infection in Matinas BioPharma’s Oral MAT2203 Compassionate/Expanded Use Access Program Achieve Complete Clinical Response - Seite 2

A 48-year-old female renal transplant recipient with a weakened immune system developed chronic non-healing leg wounds.   A fungal skin lesion culture was positive for an azole-resistant fusarium infection, which was only susceptible to amphotericin B. The patient was unable to receive long-term treatment with IV-amphotericin B due to her underlying condition, including risk for development of nephrotoxicity, and was transitioned to oral MAT2203. She began to show clinical improvement following two weeks of oral MAT2203 treatment and her skin wounds completely healed following six months of MAT2203 treatment.

A 69-year-old man with coronary artery disease, hyperlipidemia, hypertension, emphysema, aortic valve replacement, with small cell lung cancer being treated with chemotherapy, developed fever. CT scans exhibited a left upper lobe consolidation of the lung with a culture showing positive for an azole-resistant fusarium species. The patient was treated with oral MAT2203 on an out-patient basis for six months. Repeat CT scan following MAT2203 treatment showed improvement in fungal infection, with some new nodules due to progression of malignancy.

These three patients with fusarium infection are included in the 19 total patients discussed in Matinas’ recently announced update to the MAT2203 Compassionate/Expanded Use Access Program; however, two of the three patients had not yet achieved complete clinical resolution at the time of that report.

“MAT2203 continues to demonstrate its potential to effectively treat invasive fungal infections and help patients achieve complete clinical resolution. These very sick patients unfortunately are faced with a variety of complex medical challenges in addition to their fungal disease. MAT2203 has demonstrated the ability to resolve these deadly infections, allowing physicians to concentrate their efforts on the patients’ other underlying conditions,” said Jerome D. Jabbour, Chief Executive Officer of Matinas.   “If approved, an oral, effective and safe MAT2203 could represent a new treatment paradigm for the unmet medical need in the treatment of invasive fungal infections.”