RenovoRx Highlights Recent Presentation of Clinical Data Abstract at the 2024 Society of Interventional Radiology Annual Scientific Meeting - Seite 2

“Identification of the presence of MVT as a risk factor, if addressed clinically, can potentially increase frequency of patients undergoing successful TAMP procedures during treatment with proper management,” said Ramtin Agah, MD, Chief Medical Officer and Founder of RenovoRx. “It is important to understand appropriate candidates for TAMP, and managing patients who could be at any risk is paramount to helping underserved patient populations, like those diagnosed with LAPC. This is especially important given the potential of the TAMP therapy platform. The first interim analysis in the Phase III TIGeR-PaC study was completed in March 2023, with the Data Monitoring Committee recommending a continuation of the study. The TIGeR-PaC study is investigating TAMP in LAPC has a primary endpoint is a 6-month Overall Survival benefit with secondary endpoints including reduced side effects versus standard of care.”

TIGeR-PaC (NCT03257033) is currently enrolling unresectable LAPC patients at several sites across the US. To learn more about the study and the participating clinical trial sites, visit www.clinicaltrials.gov. RenovoRx’s first product candidate, RenovoGem, is a novel oncology drug-delivery combination utilizing TAMP administration technology, is currently under investigation for therapeutic delivery of the FDA-approved chemotherapy gemcitabine and has not been approved for commercial sale.

About the Phase III TIGeR-PaC Clinical Trial

TIGeR-PaC is an ongoing Phase III randomized multi-center study evaluating the proprietary TAMP (Trans-Arterial Micro-Perfusion) therapy platform for the treatment of Locally Advanced Pancreatic Cancer (LAPC). RenovoRx’s first product candidate, RenovoGem, is a novel oncology drug-delivery combination utilizing TAMP administration technology combined with the FDA-approved chemotherapy, gemcitabine. The study is comparing treatment with TAMP to the current standard of care of systemic intravenous chemotherapy.

About Locally Advanced Pancreatic Cancer (LAPC)

According to American Cancer Society’s Cancer Facts & Figures 2023, pancreatic cancer has a 5-year combined overall survival rate of 13% (Stages I-IV) and is on track to be the second leading cause of cancer-related deaths before 2030. LAPC is diagnosed when the disease has not spread far beyond the pancreas, however, has advanced to the point where it cannot be surgically removed. LAPC is typically associated with patients in Stage 3 of the disease as determined by the TNM (tumor, nodes and metastasis) grading system.