Lisata Therapeutics and Qilu Pharmaceutical Announce First Patient Treated in Qilu’s Phase 2 Trial in China of LSTA1 in Patients with Metastatic Pancreatic Ductal Adenocarcinoma - Seite 2

Preliminary data from the Qilu Phase 1b/2 trial (CEND1-201) evaluating LSTA1 (formerly known as CEND-1) in combination with nab-paclitaxel and gemcitabine demonstrated a median overall survival (mOS) of 11.1 months (CI 7.89-14.92). These data corroborate the Phase 1 trial (CEND1-001) conducted in Australia which demonstrated a mOS of 12.8 months (CI 9.9-22.8).

About LSTA1

LSTA1 is an investigational drug designed to activate a novel uptake pathway that allows co-administered or tethered anti-cancer drugs to penetrate solid tumors more effectively. LSTA1 actuates this active transport system in a tumor-specific manner, resulting in systemically co-administered anti-cancer drugs more efficiently penetrating and accumulating in the tumor. LSTA1 also has the potential to modify the tumor microenvironment resulting in tumors which are more susceptible to immunotherapies. We and our collaborators have amassed significant non-clinical data demonstrating enhanced delivery of a range of emerging anti-cancer therapies, including immunotherapies and RNA-based therapeutics. To date, LSTA1 has also demonstrated favorable safety, tolerability and clinical activity in completed and ongoing clinical trials designed to test its ability to enhance the effectiveness of standard-of-care chemotherapy for pancreatic cancer. Pursuant to the Collaboration and License Agreement, Qilu has exclusive rights to LSTA1 in Greater China, including Taiwan, Hong Kong and Macau. Accordingly, Qilu is responsible for all development and commercialization activities and costs in the licensed territories and Lisata is eligible to receive up to $221 million in remaining milestone payments across multiple indications based on certain development and commercial achievements as well as tiered double-digit royalties on product sales in the region.

About Qilu Pharmaceutical

Qilu Pharmaceutical is a leading vertically integrated pharmaceutical company focused on discovering, developing, manufacturing and commercializing both generic and innovative medicines. With a diverse pipeline of novel therapeutics, 12 manufacturing sites and more than 36,000 employees worldwide, Qilu is dedicated to transforming scientific innovation by internal R&D across 6 R&D centers based in the US (Seattle WA, Boston MA, San Francisco CA) and China (Shanghai, Jinan and Haikou), and external partnership globally into healthcare solutions to address unmet medical needs. To date, Qilu has launched 300+ products with 60+ products "First to launch" in China and 3 products "D181 launch" in US with approximately US$5.42 billion sales revenue in 2023. For more information, please visit http://en.qilu-pharma.com.