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Oral RSV Vaccine - Preclinical Data Published in Vaccine

Vaxart, Inc. (Nasdaq:VXRT), a clinical-stage biotechnology company developing oral recombinant vaccines that are administered by tablet rather than by injection, today announced publication of the preclinical results of its oral F-protein based Respiratory Syncytial Virus (RSV-F) vaccine. The findings were published in the most recent online version of Vaccine (Joyce C. et al., “Orally administered adenoviral-based vaccine induces respiratory mucosal memory and protection against RSV infection in cotton rats”).

As described in the article, the oral RSV-F vaccine candidate provided complete sterilizing protection against RSV infection in the cotton rat challenge model at the target dose. The vaccine induced significant and dose-dependent neutralizing antibody responses in serum, as well as multi-functional effector and memory B cell responses at the mucosal surface along the respiratory tract. Importantly, the Vaxart oral RSV-F vaccine did not cause any inflammatory pathology in the respiratory tract.

“Based on these results, we believe that our proprietary platform is uniquely suited as the optimal delivery system for an RSV vaccine,” said Sean Tucker, Ph.D., founder and chief scientific officer of Vaxart. “We were particularly pleased with the strong mucosal immune responses that were generated in the respiratory tract. Those trended higher even than those observed after natural infection with RSV, establishing a first line of defense against RSV infection in the respiratory tract itself. These data add to the increasing body of evidence that suggests our vaccines may provide protection through both systemic and mucosal immunity, a phenomenon we have also observed in our H1 influenza human challenge study. RSV is an important public health issue, and we look forward to building on these results.”

About Respiratory Syncytial Virus (RSV)

RSV is a major cause of acute upper (colds) and lower (pneumonia and bronchiolitis) respiratory tract infections in infants, young children, and adults. Each year in the United States, RSV accounts for an estimated 2.1 million medical visits in children under the age of five, with many of the children afflicted requiring hospitalization. The CDC estimates that each year in the United States, more than 177,000 older adults are hospitalized and 14,000 of them die due to RSV infection. At the present time there is no effective vaccine to prevent or recommended therapy to treat RSV infections.

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Oral RSV Vaccine - Preclinical Data Published in Vaccine Vaxart, Inc. (Nasdaq:VXRT), a clinical-stage biotechnology company developing oral recombinant vaccines that are administered by tablet rather than by injection, today announced publication of the preclinical results of its oral …

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