Neovacs announces in vivo Proof of Concept success for its IL-4 / IL-13 Kinoid a new Therapeutic Vaccine to treat Mite-induced Asthma

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Neovacs announces in vivo Proof of Concept success
for its IL-4 / IL-13 Kinoid a new Therapeutic Vaccine
to treat Mite-induced Asthma

• IL-4 / IL-13 Kinoid induces strong production of neutralizing antibodies against cytokines IL-4 and IL-13 and inhibits bronchoconstriction

• These results will help to define the future development in this indication in order to provide patients with long-term protection against allergic diseases.

Paris and Boston, November 7, 2018 - 5:45 pm CET- Neovacs (Euronext Growth Paris ALNEV), leader in active immunotherapy for the treatment of auto-immune and inflammatory diseases, announces today the successful in vivo proof of concept testing of its IL-4 / IL1-3 Kinoid therapeutic vaccine to treat respiratory allergies, in collaboration with a research team from the Institut Pasteur.

The IL-4 / IL-13 Kinoid, a therapeutic vaccine from Neovacs' innovative technology is designed to target allergic diseases such as asthma and food allergies. The results obtained in this preclinical study show that the vaccine is able to inhibit bronchoconstriction, and therefore to restore breathing capacity.

"These results establish a very important proof of concept for the strategy of our therapeutic products platform development based on Kinoid technology," said Miguel Sieler, CEO of Neovacs. "They validate our ability to produce effective drug candidates to treat chronic inflammatory diseases such as asthma which affects more than 300 million people worldwide^[1]."

These results were obtained in collaboration with Dr. Pierre Bruhns and Dr. Laurent Reber's research team from Antibodies in therapy and Pathology, Inserm Unit 1222, Immunology department at Institut Pasteur:"These results represent an important step in the development of a long-term treatment against allergies, for which there is still no effective long lasting solution ", says Dr. Pierre Bruhns. Dr. Laurent Reber adds: "In this study we have targeted a decisive pathway to counteract the developing allergies process, IL-4 / IL-13 Kinoid could potentially be used to treat many types of allergic conditions."