Onxeo Announces Completion of Patient Enrollment in DRIIV-1b Study and Positive Interim Results - Seite 2

About DRIIV-1b

DRIIV-1b is designed to evaluate the safety and efficacy of AsiDNA in combination with carboplatin (n=3) and carboplatin plus paclitaxel (n=6) in patients with advanced metastatic solid tumors progressing at inclusion. The efficacy of these combinations is evaluated every 6 to 8 weeks by medical imaging (Criteria for Evaluation of Response in Solid Tumors - RECIST). Out of the first seven evaluable patients, four patients, including three non-small cell lung cancer (NSCLC) patients, had a partial response and/or long control durations (no progression). For these four patients, the durations of control with either combination was consistently longer than those obtained with previous treatment lines, including other platinum-based chemotherapies or a first-line reference immunotherapy.

About Onxeo

Onxeo (Euronext Paris, NASDAQ Copenhagen: ONXEO) is a clinical-stage biotechnology company developing innovative oncology drugs targeting tumor DNA-binding functions through unique mechanisms of action in the sought-after field of DNA Damage Response (DDR). The Company is focused on bringing early-stage first-in-class or disruptive compounds from translational research to clinical proof-of-concept, a value-creating inflection point appealing to potential partners.

platON is Onxeo’s proprietary chemistry platform of oligonucleotides acting as decoy agonists, which generates new innovative compounds and broaden the Company’s product pipeline.

AsiDNA, the first compound from platON, is a first-in-class, highly differentiated DNA Damage Response (DDR) inhibitor based on a decoy and agonist mechanism acting upstream of multiple DDR pathways. Translational research has highlighted the distinctive properties of AsiDNA, notably its ability to abrogate tumor resistance to PARP inhibitors regardless of the genetic mutation status. AsiDNA has also shown a strong synergy with other tumor DNA-damaging agents such as chemotherapy and PARP inhibitors. The DRIIV-1 (DNA Repair Inhibitor-administered IntraVenously) phase I study has evaluated AsiDNA by systemic administration (IV) in advanced solid tumors and confirmed the active doses as well as a favorable human safety profile. The ongoing DRIIV-1b extension study is assessing the safety and efficacy of a 600 mg dose of AsiDNA in combination with carboplatin and then with carboplatin and paclitaxel, in patients with solid tumors who are eligible for such treatments.