Alfasigma acquires the European license for bentracimab from PhaseBio - Seite 2

"The signing of this commercialization agreement with our new partner, Alfasigma, is a truly momentous occasion for PhaseBio," said Jonathan P. Mow, Chief Executive Officer of PhaseBio Pharmaceuticals. "Alfasigma brings deep regional expertise in the hospital environment that will help unlock to the value of the global bentracimab brand while enabling PhaseBio to invest in the commercial infrastructure necessary to successfully launch the product in the United States. By establishing bentracimab in key markets where a significant proportion of the global ticagrelor patient population resides, Alfasigma will play a critical role in our mission to change the way patients on antiplatelet therapy are managed. We are excited to have found a collaborator who shares our enthusiasm for the potential of bentracimab to address critical unmet needs and look forward to a long and mutually-beneficial relationship."

Colli concludes: "Having a long experience in the therapeutic area and a consistent hospital presence, I think Alfasigma is really well positioned to bring bentracimab to clinicians and patients. The excellent harmony with PhaseBio will allow us to make bentracimab a global brand in Europe and in other key markets "

Bentracimab is currently in late-stage clinical development in the REVERSE-IT (Rapid and SustainEd ReVERSal of TicagrElor – Intervention Trial) trial. REVERSE-IT is a Phase 3, multi-center, open-label, prospective single-arm trial designed to study reversal of the antiplatelet effects of ticagrelor with bentracimab in patients who present with uncontrolled major or life-threatening bleeding or who require urgent surgery or invasive procedure. Previously, bentracimab has been studied in Phase 1 and Phase 2 clinical trials and has demonstrated the potential to bring life-saving therapeutic benefit through immediate and sustained reversal of the antiplatelet activity of ticagrelor, potentially mitigating concerns regarding bleeding risks associated with the use of this antiplatelet drug. Additionally, in a translational study, bentracimab achieved equivalent reversal of branded ticagrelor and multiple ticagrelor generics.