Relief Therapeutics Reports In Vivo Data Indicating Prolonged Release of Amino Acids Using its Physiomimic(TM) Technology May Have Benefits for the Treatment of PKU

Relief Therapeutics' Wholly Owned Subsidiary, APR Applied Pharma Research, Reports In Vivo Data Published in the Peer Reviewed, International Journal of Molecular Sciences, Indicating Prolonged Release of Amino Acids Using Its Physiomimic^TM Technology May Have Benefits for the Treatment of PKU

Data In Animal Models Suggest That APR's Controlled Release Amino Acid (AA) Mix, Formulated With the Physiomimic^TM Technology, May Have Beneficial Effects on Both AA Oxidation and Catabolism With a Direct Impact on Muscle Mass, Strength And Glyceamia

GENEVA, SWITZERLAND / ACCESSWIRE / March 29, 2022 / RELIEF THERAPEUTICS Holding SA (SIX:RLF)(OTCQB:RLFTF)(OTCQB:RLFTY) ("Relief"), a biopharmaceutical company seeking to provide patients therapeutic relief from serious diseases with high unmet need, today announced that its wholly owned subsidiary, APR Applied Pharma Research SA ("APR"), reported data published in the peer reviewed International Journal of Molecular Sciences, indicating that prolonged release of amino acids ("AA") formulated with APR's Physiomimic^TM Technology may have benefits for the dietary management of phenylketonuria ("PKU"). The full article can be accessed here.

Foto: Accesswire

The paper, entitled, "In Vivo Metabolic Responses to Different Formulations of Amino Acid Mixtures for the Treatment of Phenylketonuria (PKU)," evaluated the impact of a prolonged release of AA formulation on nitrogen balance, both in acute and long-term experimental studies to evaluate the impact on selected metabolic and functional parameters relative to the natural slow-release reference protein casein or free AA controls. Authors of the paper, including Prof. Dr. Júlio César Rocha, Assistant Professor at NOVA Medical School, Faculty of Medical Sciences, NOVA University of Lisbon Reference Centre for Inherited Metabolic Diseases - Centro Hospitalar Universitário de Lisboa Central, and CINTESIS Portugal, concluded that the prolonged release of an amino acid mix, found in PKU GOLIKE(R), may have beneficial effects on both AA oxidation and catabolism, with a direct impact on muscle mass and muscle strength as well as on other metabolic pathways such as glycaemia, in normal rats. The results of this study also supported further studies in human subjects aimed at demonstrating the beneficial effects of the Physiomimic^TM Technology AA formulation for the dietary treatment of PKU.