TME Pharma

Half-yearly Report on the Liquidity Contract With Invest Securities

Regulatory News:

TME Pharma N.V. (Euronext Growth Paris: ALTME) (Paris:ALTME), a biotechnology company focused on developing novel therapies for treatment of cancer by targeting the tumor microenvironment (TME), announced today that pursuant to the liquidity contract entrusted to Invest Securities by TME Pharma N.V. the assets outlined below appeared on the liquidity account. During the reporting period the company changed its name from NOXXON Pharma to TME Pharma (July 15, 2022), and effected a share consolidation such that every 100 shares with a nominal value of 1 eurocent each were consolidated and converted into 1 new share with a nominal value of 1 euro (July 27, 2022). Both processes are being reflected in this half-yearly report.

The following assets appeared on the liquidity account as of December 31, 2022:

• Number of shares: 13,992

• Cash balance of the liquidity account: €11,622.12

For the period July 28, 2022 – December 31, 2022:

• Total number of shares bought: 81,080

representing an amount of: €217,453.70

representing total transactions of: 1,222

• Total number of shares sold: 67,779

representing an amount of: €185,844.42

representing total transactions of: 1,519

The company made an additional payment of €15,000.00 on November 23, 2022, into the liquidity account in order to improve the balance and maintain the liquidity contract. For more detailed information for the period of July 28, 2022 – December 31, 2022, please see annex A of this press release.

The following assets appeared on the liquidity account as of July 27, 2022:

• Number of shares: 691 (equating to 69,192 before the share consolidation)

• Cash balance of the liquidity account: €28,231.41

For the period July 01, 2022 – July 27, 2022:

• Total number of shares bought: 47,517

representing an amount of: €2,173.69

representing total transactions of: 33

• Total number of shares sold: 64,518

representing an amount of: €3,260.45

representing total transactions of: 42

As a reminder, as of June 30, 2022, the following assets appeared on the liquidity account:

• Number of shares: 86,193

• Cash balance of the liquidity account: €27,144.62

For more detailed information for the period of July 01, 2022 – July 27, 2022, please see annex B of this press release.

About TME Pharma

TME Pharma is a clinical-stage company focused on developing novel therapies for treatment of the most aggressive cancers. The company’s oncology-focused pipeline is designed to act on the tumor microenvironment (TME) and the cancer immunity cycle by breaking tumor protection barriers against the immune system and blocking tumor repair. By neutralizing chemokines in the TME, TME Pharma’s approach works in combination with other forms of treatment to weaken tumor defenses and enable greater therapeutic impact. In the GLORIA clinical trial, TME Pharma is studying its lead drug candidate NOX-A12 in newly diagnosed brain cancer patients who will not benefit clinically from standard chemotherapy. TME Pharma has delivered top-line data from the NOX-A12 three dose-escalation cohorts combined with radiotherapy of the GLORIA clinical trial, observing consistent tumor reductions and objective tumor responses. Additionally, GLORIA expansion arms evaluate safety and efficacy of NOX-A12 in other combinations where the interim results from the triple combination of NOX-A12, radiotherapy and bevacizumab suggest even deeper and more durable responses. NOX-A12 in combination with radiotherapy has received orphan drug designation for glioblastoma in the United States and glioma in Europe. TME Pharma has delivered final top-line data with encouraging overall survival and safety profile from its NOX-A12 combination trial with Keytruda in metastatic colorectal and pancreatic cancer patients, which was published in the Journal for ImmunoTherapy of Cancer in October 2021. The company has entered in its second collaboration with MSD/Merck for its Phase 2 study, OPTIMUS, to further evaluate safety and efficacy of NOX-A12 in combination with Merck’s Keytruda and two different chemotherapy regimens as second-line therapy in patients with metastatic pancreatic cancer. The design of the trial is in discussion with regulatory authorities in the United States and Europe. The company’s second clinical-stage drug candidate, NOX-E36, is designed to target the innate immune system. TME Pharma is considering several solid tumors for further clinical development. Further information can be found at: www.tmepharma.com.