Allarity Therapeutics Accelerates Trial Enrollment To Bring FDA-Approved Breast Cancer Treatment To European Market - Interim Results Could Be Released In Second Half Of 2023 - Seite 2

The good news is that cancer researchers are identifying more and more biomarkers that can predict whether or not an individual patient's cancer will respond to a particular drug. That includes biomarkers that indicate if a cancer is especially resistant to a drug and biomarkers that suggest if it might be especially vulnerable to it.

However, there's no single gene or biomarker that definitively proves a drug will or will not work. Instead, dozens if not hundreds of genes and biomarkers are at play and a single patient can often have a mix of both resistant and susceptible biomarkers.

That cancer complexity is why Allarity developed the DRP® platform. Using drug-specific DRP® companion diagnostics, doctors will be able to not only rule out drugs that a patient is unlikely to respond to but hone in on the course of treatment with the best chance of producing the best results. This can save thousands of dollars for patients by avoiding ineffective treatments and improve their odds of remission by getting them on the right treatment for their particular cancer as soon as possible.

Already deployed in over 47 cancer trials, the DRP® platform technology has yielded a high success rate with more than 80% predictive accuracy thanks to its systems biology analysis approach. Starting with analysis of messenger RNA taken from cancer cell lines treated with a given drug, the DRP® platform generates an initial gene expression signature that predicts whether a tumor will (or will not) respond to the drug. The DRP® platform then refines this predictive signature through a proprietary clinical relevance filter comprising drug response/resistance data from thousands of biopsy samples from actual patients in prior oncology clinical trials. The result is a unique DRP® signature (or companion diagnostic) based on 50 to 400 biomarkers. That signature can then be compared to messenger RNA data from a specific patient's tumor to generate a DRP® score, a measure of how likely the patient is to respond to that drug.

In the IXEMPRA® trial, for example, Allarity is enrolling patients with at least a 33% DRP® score for the breast cancer therapy. In addition to measuring the efficacy of the therapy, the trial will also be used to further validate the predictive accuracy of the DRP® companion diagnostic by comparing response rates to patients' initial DRP® scores.

As the company implements the amended trial protocol to speed up enrollment, by having lowered the IXEMPRA-DRP® companion diagnostic cut-off score, for enrollment, from 67% to 33%, and by expanding its CRO partnerships, meaning more sites will participate in the trial, it's working to advance towards hopeful approval for the European market, where Allarity holds exclusive option rights to the drug.

Featured photo by National Cancer Institute on Unsplash

Contact:

US investor contact:
Thomas Jensen,
[e-mail]
[phone]

EU investor contact:
Thomas Pedersen
[e-mail]
[phone]

SOURCE: Allarity Therapeutics, Inc.

View source version on accesswire.com:
https://www.accesswire.com/751439/Allarity-Therapeutics-Accelerates-Trial-Enrollment-To-Bring-FDA-Approved-Breast-Cancer-Treatment-To-European-Market--Interim-Results-Could-Be-Released-In-Second-Half-Of-2023


The Allarity Therapeutics Stock at the time of publication of the news with a fall of -8,71 % to 0,437USD on NYSE stock exchange (27. April 2023, 02:00 Uhr).