KalVista Pharmaceuticals Presents New Data at 2023 Meeting of the European Academy of Allergy and Clinical Immunology

KalVista Pharmaceuticals, Inc. (NASDAQ: KALV), a clinical stage pharmaceutical company focused on the discovery, development, and commercialization of oral, small molecule protease inhibitors, today announced that it presented data on sebetralstat and quality of life issues experienced by people living with hereditary angioedema (HAE) at the 2023 Meeting of the European Academy of Allergy and Clinical Immunology (EAACI) in Hamburg, Germany.

The following presentations occurred at EAACI 2023:

• Results From a Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial Evaluating Sebetralstat Pharmacokinetics, Pharmacodynamics, and Safety/Tolerability in Healthy Japanese, Chinese, and White Adults: Michihiro Hide, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan (Flash Talk)
• Short-Term Prophylaxis with Sebetralstat, an Investigational Oral On-Demand Treatment for Hereditary Angioedema, in KONFIDENT-S: Jonathan A. Bernstein, University of Cincinnati College of Medicine and Bernstein Clinical Research Center, LLC, Cincinnati, OH, US (Poster Presentation)
• Remaining burden of hereditary angioedema (HAE) attacks despite modern long-term prophylaxis: Stephen Betschel, Division of Allergy and Immunology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, ON Canada (Flash Talk)
• Understanding the complex decision-making associated with on-demand treatment of hereditary angioedema (HAE) attacks: Anete Grumach, Centro Universitário Faculdade de Medicina do ABC (FMABC), Santo André, Brazil (Poster Presentation)
• Patients delay treating hereditary angioedema (HAE) attacks with currently available, injectable, on-demand therapies: associated with on-demand treatment of hereditary angioedema (HAE) attacks: Anna Valerieva, Medical University of Sofia, Sofia, Bulgaria (Poster Presentation, also selected for the EAACI Junior Member Poster Session)

The first presentation highlighted consistencies in pharmacokinetics and pharmacodynamics for sebetralstat across healthy Japanese, Chinese and White adult populations, supporting the continued global expansion of the ongoing KONFIDENT phase 3 trial assessing the efficacy and safety of sebetralstat for on-demand use in HAE attacks, while the second presentation outlines the rationale for sebetralstat as a potential treatment to prevent HAE attacks that may be triggered by invasive medical or dental procedures. KalVista is currently assessing sebetralstat as an oral, short-term prophylaxis in KONFIDENT-S, the two-year open-label extension study for the KONFIDENT phase 3 trial.