TransCode Therapeutics CEO Letter to Shareholders - Seite 4

Over the past two years, the biotech sector has faced a substantial downturn that industry experts consider the most significant in the last two decades. Our success in raising capital from institutional investors against this backdrop further encourages us that we are on the right track. Major pharmaceutical companies are compelled to actively seek fresh drug candidates to renew their pipelines ahead of impending patent expirations. Development stage biotech companies, such as TransCode Therapeutics, play a crucial role as the sources from which these large companies discover their next potential candidates.

As we look ahead, we remain steadfast in our commitment to advancing our pipeline, expanding collaborations, and exploring new therapeutic avenues. Our goal is to continue pushing the boundaries of what is possible in the field of oncology, bringing hope to patients and transforming the treatment landscape. We are hopeful that our targeted therapeutic delivery platform, exemplified by the progress of TTX-MC138, will play a pivotal role in realizing this vision.

We are filled with anticipation for the future as we strive to establish ourselves as a leading oncology company, potentially offering millions of patients a viable treatment solution for metastatic disease. Our aim is to alleviate the fear that cancer patients experience when facing the possibility of their cancer spreading without a treatment solution. We firmly believe that we have the potential to emerge as the pioneering company that delivers this crucial and much-needed solution.

Thank you for your investment in TransCode. We are excited about the future and look forward to sharing further updates on our progress in the coming months.

Sincerely,

R. Michael Dudley
Chief Executive Officer and Co-Founder
TransCode Therapeutics Inc.

About TransCode Therapeutics

TransCode is an RNA oncology company created on the belief that cancer can be more effectively treated using RNA therapeutics. The Company has created a platform of drug candidates designed to target a variety of tumor types with the objective of significantly improving patient outcomes. The Company’s lead therapeutic candidate, TTX-MC138, is focused on treating metastatic cancer, which is believed to cause approximately 90% of all cancer deaths totaling over nine million per year worldwide. The Company believes that TTX-MC138 has the potential to dramatically improve clinical outcomes in a range of cancers, including breast, pancreatic, ovarian and colon cancer, glioblastomas and others. Two of the Company’s other drug candidates, TTX-siPDL1 and TTX-siLIN28B, focus on treating tumors by targeting PD-L1 and LIN28B, respectively. TransCode also has three cancer-agnostic programs: TTX-RIGA, an RNA–based agonist of the retinoic acid-inducible gene I designed to drive an immune response in the tumor microenvironment; TTX-CRISPR, a CRISPR/Cas9–based therapy platform for the repair or elimination of cancer-causing genes inside tumor cells; and TTX-mRNA, an mRNA-based platform for the development of cancer vaccines designed to activate cytotoxic immune responses against tumor cells.