Newly Published Results Reveal a Significant Proportion of Early-Stage HR+ Breast Cancer Survivors May Be Over- or Undertreated Without Breast Cancer Index Genomic Testing - Seite 4

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¹Sanft T, Wong J, O’Neal B, et al. Impact of the Breast Cancer Index for Extended Endocrine Decision-Making: First Results of the Prospective BCI Registry Study. Journal of The National Comprehensive Cancer Network. Published online March 04, 2024. doi:10.6004/jnccn.2023.7087
²Davies C, Pan H, Godwin J, et al. Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial. The Lancet. 2013;381(9869):805-816. doi:https://doi.org/10.1016/s0140-6736(12)61963-1
³Gray RG, Rea D, Handley K, et al. aTTom: Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years in 6,953 women with early breast cancer. Journal of Clinical Oncology. 2013;31(18_suppl):5-5. doi:https://doi.org/10.1200/jco.2013.31.18_suppl.5
⁴Jakesz R, Greil R, Gnant M, et al. Extended Adjuvant Therapy With Anastrozole Among Postmenopausal Breast Cancer Patients: Results From the Randomized Austrian Breast and Colorectal Cancer Study Group Trial 6a. Journal of the National Cancer Institute. 2007;99(24):1845-1853. doi:https://doi.org/10.1093/jnci/djm246
⁵Goss PE, Ingle JN, Martino S, et al. Randomized Trial of Letrozole Following Tamoxifen as Extended Adjuvant Therapy in Receptor-Positive Breast Cancer: Updated Findings from NCIC CTG MA.17. Journal of the National Cancer Institute. 2005;97(17):1262-1271. doi:https://doi.org/10.1093/jnci/dji250
⁶Mamounas EP, Bandos H, Lembersky BC, et al. A randomized trial of five years of letrozole versus placebo after aromatase inhibitor-based therapy: NRG Oncology/NSABP B-42. The Lancet Oncology. 2019;20(1):88-99. doi:https://doi.org/10.1016/S1470-2045(18)30621-1
⁷Goss PE, Ingle JN, Pritchard KI, et al. Extending Aromatase-Inhibitor Adjuvant Therapy to 10 Years. New England Journal of Medicine. 2016;375(3):209-219. doi:https://doi.org/10.1056/nejmoa1604700
⁸Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Breast Cancer V.4.2023. National Comprehensive Cancer Network, Inc. 2023. All rights reserved. Accessed December 15, 2023. To view the most recent and complete version of the guideline, go online to NCCN.org. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.

SOURCE: Hologic, Inc.

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