ARS Pharmaceuticals Reviews Recent Clinical Updates and Commercial Opportunity at neffy Investor Day

• Significant unmet need with 80-90% of patients with current epinephrine Rx not using as directed, and only ~15% of diagnosed severe Type I allergy population with a current epinephrine prescription
• Multiple favorable attributes and potential best-in-class profile of neffy highlighted at the event
• Potential for epinephrine market to significantly expand from today due to availability of neffy
  

SAN DIEGO, March 07, 2024 (GLOBE NEWSWIRE) -- ARS Pharmaceuticals, Inc. (Nasdaq: SPRY), a biopharmaceutical company dedicated to empowering at-risk patients and caregivers to better protect patients from severe allergic reactions that could lead to anaphylaxis, today hosted an investor event highlighting neffy (epinephrine nasal spray), an investigational new drug, for the treatment of Type I allergic reactions. The event included presentations by members of the ARS Pharma management team and by two distinguished allergists, Dr. Jonathan Spergel, M.D., Ph.D. and Dr. Thomas B. Casale, M.D.

“During our neffy Investor Day, we highlighted the substantial unmet need faced by patients suffering from severe allergies, and how current epinephrine treatments, while effective, have limitations – largely stemming from needle-related risks and portability issues,” said Richard Lowenthal, Co-Founder, President and CEO of ARS Pharma. “Dr. Spergel and Dr. Casale discussed the limitations of today’s needle-based treatments and how a product with neffy’s profile increases the likelihood that patients will easily carry and confidently administer epinephrine without anxiety or hesitation. We believe we have addressed the deficiencies identified in FDA’s CRL for neffy, and we expect to submit a response early in the second quarter of 2024 and, if approved, look forward to bringing this innovative treatment to patients.”

Dr. Jonathan Spergel, M.D., Ph.D., Professor of Pediatrics and Chief of the Allergy Program at Children’s Hospital of Philadelphia, commented, “Epinephrine has been used for more than 100 years and we know that it is an effective treatment to reverse the symptoms of anaphylaxis, yet approximately 40% of patients do not fill their epinephrine prescriptions. Of the patients that do fill their prescription, 80-90% either do not carry or use their treatment as indicated. Prompt administration of epinephrine is the most critical factor that translates to better efficacy, regardless of device. The availability of an additional epinephrine option will help with compliance, especially with respect to children who account for almost half of the population with active prescriptions today.”