Incyte Presents New Late-Breaking Data from Phase 2 Study Evaluating Povorcitinib in Patients with Prurigo Nodularis - Seite 2

“PN can often be difficult to treat due to the uncontrollable itching and scratching, which can multiply the nodules that appear on a patient’s skin,” said Dr. Martin Metz, Professor of Dermatology and Allergy, Charité. “Breaking the itch-scratch cycle is imperative when treating patients with PN, and I’m encouraged by these results illustrating improvement in itch and also skin clearance by Week 16 which shows promise for povorcitinib as a potential novel treatment option for these patients.”

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About Prurigo Nodularis

Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by intense itch and thickened red bumps on the arms, legs and trunk.¹ Due to the result of persistent, intense scratching and rubbing of the skin, PN results in itchy bumps on the skin called “nodules”.² PN appears to be more common in older individuals, and the painful bumps and constant itch can have a substantial impact on a patient’s sleep and overall quality of life.¹

About the Phase 2 Study (NCT05061693)

This randomized, double-blind, placebo-controlled Phase 2 clinical trial is designed to evaluate the safety and efficacy of povorcitinib (INCB54707) in adult patients with prurigo nodularis (PN), over 16 weeks, followed by a 24-week extension. The study consists of 146 adult patients (age ≥ 18 years) diagnosed with PN who have had inadequate response or are intolerant to prior PN therapy.

The primary outcome measure of the study is proportion of participants achieving ≥ 4-point improvement in itch Numerical Rating Scale (NRS) score over 16 weeks. The secondary outcome measures include proportion of participants achieving Investigator's Global Assessment Treatment Success (IGA-TS) at Week 16, the proportion of patients achieving both IGA-TS and a ≥ 4-point improvement from baseline in itch NRS score assessed up to Week 16 and number of participants experiencing treatment-emergent adverse events (TEAEs), assessed up to Week 16.

For more information about the study, please visit https://classic.clinicaltrials.gov/ct2/show/NCT05061693.

About Povorcitinib (INCB54707)

Povorcitinib (INCB54707) is an oral small-molecule JAK1 inhibitor currently in Phase 3 clinical trials for hidradenitis suppurativa (HS) and vitiligo. A Phase 3 trial is being planned for prurigo nodularis (PN). Phase 2 studies of povorcitinib in PN, asthma and chronic spontaneous urticaria are also ongoing.