Gritstone bio Highlights the Durability and Potential Broad Utility of its Self-amplifying mRNA (samRNA) COVID-19 Vaccine at ESCMID Global 2024

-- IgG levels and neutralizing antibodies against variants of concern persisted for at least 12 months, consistent with previous findings --

-- Antigen-specific T cell responses increased in the majority of participants studied, including those living with HIV, after administration of any of the samRNA constructs --

-- Comprehensive data set demonstrates a consistent and strong immunogenicity profile across multiple patient populations in South Africa, including people living with HIV --

EMERYVILLE, Calif., April 30, 2024 (GLOBE NEWSWIRE) -- Gritstone bio, Inc. (Nasdaq: GRTS), a clinical-stage biotechnology company working to develop the world’s most potent vaccines, today presented updated Phase 1 data from its CORAL-CEPI study, a Coalition for Epidemic Preparedness Innovations (CEPI)-funded study that is evaluating Gritstone’s self-amplifying mRNA (samRNA) vaccine against COVID-19 in HIV-negative and people living with HIV (PLWH) participants. The presentation, at ESCMID Global 2024, reviewed the latest findings demonstrating the durability and potential broad utility of Gritstone’s samRNA vaccine against COVID-19. The new findings came from Group D, which evaluated immunogenicity of Gritstone’s samRNA vaccine candidate delivering the Spike BA.1 variant as compared to the Spike Beta variant evaluated in Groups A-C.

“The data presented at ESCMID Global, our most comprehensive Phase 1 dataset to date, highlights the potential of our samRNA vaccine to generate robust and durable immune responses across a diverse set of populations; naïve, convalescent and previously vaccinated,” said Andrew Allen, M.D., Ph.D., Co-founder, President, and Chief Executive Officer of Gritstone bio. “Previously, we had shown our samRNA vaccine capable of driving potentially broad and durable protection through 12 months across three Phase 1 studies spanning multiple other populations and settings. The new findings announced today demonstrate the vaccine is capable of driving broad and durable B and T cell responses in previously unvaccinated or vaccinated individuals in South Africa, including in people living with HIV. These results add to the growing body of evidence suggesting this differentiated immune response extends beyond healthy individuals and potentially to the most vulnerable of patients.”