Shire's First Prescription Eye Drop, Xiidra(TM) (lifitegrast ophthalmic solution) 5% is Now Available in the U.S. - Seite 2

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About Xiidra(TM) (lifitegrast ophthalmic solution) 5%

Xiidra(TM) (lifitegrast ophthalmic solution) 5% is a prescription
eye drop indicated for the treatment of signs and symptoms of dry eye
disease. It is dosed twice per day, approximately 12 hours apart, in
each eye. The active ingredient in Xiidra, lifitegrast, binds to the
integrin lymphocyte function-associated antigen-1 (LFA-1), a cell
surface protein found on leukocytes, and blocks the interaction of
LFA-1 with its cognate ligand intercellular adhesion molecule-1
(ICAM-1). ICAM-1 may be overexpressed in corneal and conjunctival
tissues in patients with dry eye disease. This interaction can
contribute to the formation of an immunological synapse resulting in
T-cell activation and migration to target tissues. In vitro studies
demonstrated that lifitegrast may inhibit T-cell adhesion to ICAM-1
in a human T-cell line and may inhibit secretion of inflammatory
cytokines in human peripheral blood mononuclear cells. The exact
mechanism of action of lifitegrast in dry eye disease is not known.
Xiidra is packaged in a foil pouch containing five low density
polyethylene 0.2 mL single-use containers, and is supplied in a
carton of 60 single use containers.

Important Safety Information

The most common side effects of Xiidra include eye irritation,
discomfort or blurred vision when the drops are applied to the eyes,
and an unusual taste sensation (dysgeusia). To help avoid eye injury
or contamination of the solution, do not touch the container tip to
your eye or any surface. If you wear contact lenses, remove them
before using Xiidra and wait for at least 15 minutes before placing
them back in your eyes.

It is not known if Xiidra is safe and effective in children under
17 years of age.

For additional information, click here
(http://www.shirecontent.com/PI/PDFS/XIIDRA_USA_ENG.pdf) for full
Prescribing Information including Patient Information and discuss
with your doctor.

You are encouraged to report negative side effects of prescription
drugs to the FDA. Visit http://www.fda.gov/medwatch or call
1-800-FDA-1088.

About Dry Eye Disease

Dry eye is a multifactorial disease of the tears and ocular
surface. It is diagnosed by an eye care professional based on patient
reported symptoms, such as eye dryness, overall eye discomfort,
stinging, burning, a gritty feeling or fluctuating blurry vision, as
well as signs, which can be objectively evaluated by an eye care
professional through various tests to determine the presence of dry