Idorsia initiates a multiple-dose efficacy and safety study with cenerimod for the treatment of systemic lupus erythematosus - Seite 3

T and B lymphocytes have receptors on the surface called "Sphingosine-1-phosphate receptor 1" (S1P₁). This receptor senses the gradient of sphingosine-1-phosphate or S1P, which is high in blood, guiding the lymphocytes out of lymph nodes towards the circulation.

Cenerimod, a selective S1P₁ receptor modulator, binds to the S1P₁ receptor on the surface of T and B lymphocytes. This interaction leads to internalization of the S1P₁ receptor, so that the lymphocyte can no longer sense S1P. As a result, the lymphocytes are held in the lymph nodes, reducing the availability of these key players in inflammation to the affected organs and tissues. The effect of cenerimod on lymphocyte trafficking is reflected by the dose-dependent, sustained and reversible reduction in circulating lymphocyte counts observed upon administration of cenerimod.

Key scientific literature
1.        Piali L, et al. Pharmacol Res Perspect. 2017 Dec;5(6).
2.        Borchers AT, et al. Autoimmun Rev. 2010; 9(5):A277-87.
3.        Pons-Estel GJ, et al. Semin Arthritis Rheum. 2010; 39(4):257-68.
4.        Govoni M, et al. Lupus. 2006; 15:110-113.
5.        Rahman A, Isenberg DA. N Engl J Med. 2008; 358:929-39.
6.        Abu-Shakra M, et al. J Rheumatol 1995; 22(7):1259-64.

About Idorsia
Idorsia Ltd is reaching out for more - We have more ideas, we see more opportunities and we want to help more patients. In order to achieve this, we will develop Idorsia into one of Europe's leading biopharmaceutical companies, with a strong scientific core.

Headquartered in Switzerland - a biotech-hub of Europe - Idorsia is specialized in the discovery and development of small molecules, to transform the horizon of therapeutic options. Idorsia has a broad portfolio of innovative drugs in the pipeline, an experienced team, a fully-functional research center, and a strong balance sheet - the ideal constellation to bringing R&D efforts to business success.

Idorsia was listed on the SIX Swiss Exchange (ticker symbol: IDIA) in June 2017 and has over 700 highly qualified specialists dedicated to realizing our ambitious targets.

For further information, please contact
Andrew C. Weiss
Senior Vice President, Head of Investor Relations & Corporate Communications
Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, CH-4123 Allschwil
[phone]
www.idorsia.com

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