Marinus Pharmaceuticals to Host Pipeline Update Webinar - Seite 3

Darcy Krueger M.D., Ph.D. is Director of the Tuberous Sclerosis Clinic, Associate Professor of Clinical Pediatrics and Neurology, and Associate Director of Research in Neurology at Cincinnati Children’s Hospital Medical Center. He is a founding member of the Tuberous Sclerosis Complex Clinical Research Consortium and served as its first Director from 2011 to 2013. Dr. Krueger received PhD and MD degrees from Saint Louis University in 2000 and 2002, respectively, and completed a combined residency in pediatrics, neurology, and child neurology at Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine in 2007. Dr. Krueger was a leading investigator for the landmark clinical trial using mTOR inhibitors to treat subependymal giant cell astrocytomas that led to the first ever FDA-approved treatment for TSC in 2010. Dr. Krueger leads multiple clinical research studies in TSC, including the TSC Autism Center of Excellence Network funded by the National Institutes of Health and the TS Alliance. Additional projects are aimed at better understanding the underlying mechanisms of TSC disease pathogenesis and treatment response, with the ultimate objective of developing treatment strategies that reverse or prevent disease progression and secondary complications.

About Marinus Pharmaceuticals
Marinus Pharmaceuticals, Inc. is a pharmaceutical company dedicated to the development of innovative therapeutics to treat rare seizure disorders. Ganaxolone is a positive allosteric modulator of GABA_A receptors that acts on a well-characterized target in the brain known to have anti-seizure, anti-depressant, and anti-anxiety effects. Ganaxolone is being developed in IV and oral dose forms intended to maximize therapeutic reach to adult and pediatric patient populations in both acute and chronic care settings. Marinus is conducting the first ever Phase 3 pivotal trial in children with CDKL5 deficiency disorder, along with a Phase 2 trial in Tuberous Sclerosis Complex, and a Phase 2 biomarker driven proof of concept trial in PCDH19-related epilepsy. The Company is initiating a Phase 3 trial in status epilepticus.
           
CONTACT: 
Sasha Damouni Ellis
Vice President, Investor Relations & Corporate Communications
Marinus Pharmaceuticals, Inc.
484-253-6792
[e-mail]