Cyclerion Announces Translational Research Award from the Alzheimer’s Association Part the Cloud-Gates Partnership Grant Program

CAMBRIDGE, Mass., Aug. 25, 2020 (GLOBE NEWSWIRE) -- Cyclerion Therapeutics, Inc. (Nasdaq: CYCN), a clinical-stage biopharmaceutical company developing treatments for serious and orphan diseases, today announced that it has been awarded a grant from the Alzheimer's Association’s Part the Cloud-Gates Partnership Grant Program. This award will support the Company’s upcoming Phase 2 trial of IW-6463 in Alzheimer’s Disease with vascular pathology (ADv). The award provides Cyclerion with $2 million of funding over the next 2 years.

“We are very pleased to have won this highly competitive award from the Alzheimer’s Association Part the Cloud-Gates Partnership Grant Program. Human genetic evidence and preclinical data suggest that stimulation of soluble guanylate cyclase (sGC) with IW-6463 can alleviate neurodegenerative pathology at the cellular level and thereby restore neuronal health and function. The clinical work supported by this grant will further our understanding of treatment potential of our approach and inform our efforts to find meaningful new treatments for dementias,” said Andy Busch, Ph.D., Cyclerion’s Chief Innovation Officer

“As a practicing neurologist I have seen first-hand the devastating impact that dementias have on patients and their families.  Patients and physicians are eager for better therapies and we need to explore new mechanistic approaches. We believe that IW-6463 has the potential to improve cognitive symptoms of dementia and may also be disease modifying – changing the course of many neurodegenerative diseases via potential neurovascular, neuroprotective, cellular bioenergetic, and neurophysiological benefits,” said Chris Wright, M.D., Cyclerion’s Chief Medical Officer.

IW-6463 has successfully completed a Phase 1 study and is now being studied in a translational pharmacology study in elderly participants. Top line data from this study are expected in September 2020. Cyclerion R&D leaders and independent experts reviewed the company’s CNS program in a webcast investor event on July 9, 2020. The presentation and transcript from that event are available at the “Investors and Media” section of the Cyclerion website: https://ir.cyclerion.com/news-events/presentations

About Cyclerion Therapeutics 
Cyclerion Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of sGC pharmacology to discover, develop, and commercialize breakthrough treatments for serious and orphan diseases. Lead programs include its vascular-targeted olinciguat in Phase 2 development for sickle cell disease and IW-6463, a pioneering CNS-penetrant sGC stimulator in clinical development for Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like episodes (MELAS) and Alzheimer's Disease with Vascular pathology (ADv).